Polymorphism at codon 72 of the p53 gene in human acute myelogenous leukemia.
Polymorphism at codon 72 of the p53 gene in human acute myelogenous leukemia.
复制标题
人急性髓性白血病 p53 基因密码子 72 的多态性。
DOI：
10.1016/0378-1119(92)90738-b
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发表时间：
1992
期刊：
影响因子：
3.5
通讯作者：
Deisseroth,A
中科院分区：
文献类型：
--
作者：
Zhang,W;Hu,G;Deisseroth,A
A common polymorphism at codon 72 of thep53 gene in patients with acute myelogenous leukemia (AML) was analyzed by single-strand conformation polymorphism assay and sodium dodecyl sulfate polyacrylamide-gel electrophoresis of immunoprecipitated35S-labeled P53 protein. No association between this polymorphism and a marked predisposition to AML was found. The half-lives of these two polymorphic forms of P53 were equivalent in normal phytohemagglutinin-stimulated lymphocytes, while the P53 Pro72isoform was found to be twice as stable as the Arg72isoform in Daudi cells.
通过 cDNA 聚合酶链反应产物的单链构象多态性分析检测人肺癌细胞系中视网膜母细胞瘤基因的失活。
影响因子：
8
作者：
Y. Murakami;M. Katahira;R. Makino;K. Hayashi;S. Hirohashi;T. Sekiya
通讯作者：
T. Sekiya
影响因子：
56.9
作者：
HOLLSTEIN, M;SIDRANSKY, D;HARRIS, CC
通讯作者：
HARRIS, CC
影响因子：
56.9
作者：
BAKER, SJ;MARKOWITZ, S;VOGELSTEIN, B
通讯作者：
VOGELSTEIN, B