LYMPHOCYTES-T INHIBIT THE VASCULAR-RESPONSE TO INJURY
LYMPHOCYTES-T INHIBIT THE VASCULAR-RESPONSE TO INJURY
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DOI：
10.1073/pnas.88.23.10530
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发表时间：
1991-12-01
影响因子：
11.1
通讯作者：
FINGERLE, J
中科院分区：
文献类型：
--
作者：
HANSSON, GK;HOLM, J;FINGERLE, J
The proliferation of vascular smooth muscle cells is controlled by specific growth factors and cytokines acting in paracrine networks. Macrophage products such as the platelet-derived growth factor and interleukin 1 promote smooth muscle proliferation and are released in the arterial wall during atherosclerosis and repair processes. T lymphocytes are also present in vascular tissue, but their role in vascular growth control in vivo has been unclear. We now demonstrate that rats in which T lymphocytes have been eliminated by a monoclonal antibody develop larger proliferative arterial lesions after balloon-catheter injury. Larger lesions also develop in athymic rnu/rnu rats that lack T lymphocytes, when compared with rnu/+ littermates with normal T-cell levels. Finally, injection of the lymphokine interferon-gamma inhibits smooth muscle proliferation and results in smaller lesions compared with controls injected with buffer alone. These results indicate that T lymphocytes modulate smooth muscle proliferation during vascular repair. We propose that T lymphocytes may play an important, immunologically nonspecific role in tissue repair processes.
