Preparation and characterization of IPN hydrogels composed of chitosan and gelatin cross-linked by genipin
Preparation and characterization of IPN hydrogels composed of chitosan and gelatin cross-linked by genipin
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DOI：
10.1016/j.carbpol.2013.08.048
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发表时间：
2014-01-02
影响因子：
11.2
通讯作者：
Zhu, Ping
中科院分区：
文献类型：
--
作者：
Cui, Li;Jia, Junfang;Zhu, Ping
以京尼平为交联剂，制备并表征了基于壳聚糖和明胶的互穿聚合物网络（IPN）水凝胶。通过特性粘度测量、傅里叶变换红外光谱（FT-IR）、扫描电子显微镜（SEM）和茚三酮测定证实了京尼平交联壳聚糖/明胶水凝胶的IPN形成。特性粘度测量、FT-IR和SEM表明壳聚糖和明胶在分子水平上是互溶的。这种混溶性导致交联后形成IPN。 FT-IR 还检查了京尼平与伯氨基的交联机制。交联程度随着京尼平浓度的增加而增加。溶胀结果表明，IPN 水凝胶对 pH 值敏感，表现出可逆性，并且溶胀对 pH 值变化的响应相当快。预计这种 IPN 水凝胶具有作为受控药物输送系统或在 pH 值改变时作为生物医学和环境用途的替代吸附剂的潜力。 (C) 2013 Elsevier Ltd. 保留所有权利。
The interpenetrating polymer networks (IPN) hydrogels based on chitosan and gelatin using genipin as the cross-linker were prepared and characterized. The IPN formation of the genipin-cross-linked chitosan/gelatin hydrogel was confirmed by means of the instrinsic viscosity measurement, Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) and the ninhydrin assays. The instrinsic viscosity measurement, FT-IR and SEM suggested that chitosan and gelatin were miscible in the molecular level. The miscibility leads to the formation of IPN after cross-linking. FT-IR also examined the cross-linking mechanism of genipin with primary amino groups. The degree of cross-linking increased with increase genipin concentration. Swelling results revealed that the IPN hydrogels are pH-sensitive, exhibiting reversibility and rather rapidly response in swelling to pH changes. It is expected this IPN hydrogel has potential as controlled drug delivery system or as alternative sorbents for biomedical and environmental use as pH altered. (C) 2013 Elsevier Ltd. All rights reserved.