CYCLIC 2',3'-PHOSPHATES AND NONTEMPLATED NUCLEOTIDES AT THE 3' END OF SPLICEOSOMAL U6 SMALL NUCLEAR RNAS
CYCLIC 2',3'-PHOSPHATES AND NONTEMPLATED NUCLEOTIDES AT THE 3' END OF SPLICEOSOMAL U6 SMALL NUCLEAR RNAS
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DOI：
10.1126/science.1549778
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发表时间：
1992-01-17
期刊：
影响因子：
56.9
通讯作者：
DAHLBERG, JE
中科院分区：
文献类型：
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作者：
LUND, E;DAHLBERG, JE
人类、青蛙、果蝇和大豆等多种物种的剪接体 U6 小核 RNA (U6 RNA) 在其 3' 末端具有环状 2',3'-磷酸 (> p)，显然源自转录后添加的尿苷酸残基。不同来源的 U6 RNA 的 3' 末端可能会以不同的方式或不同的程度进行加工，具体取决于生物体或发育阶段。 U6 RNA 上 a > p 末端的存在可能会在剪接过程中直接影响 U6 RNA 的活性，或通过确保 RNA 具有确定的长度或正确的构象（或两者）来间接影响 U6 RNA 的活性。
Spliceosomal U6 small nuclear RNA (U6 RNA) in species as diverse as man, frog, fruitfly, and soybean have at their 3' ends a cyclic 2',3'-phosphate (> p) apparently derived from uridylic acid residues that were added post-transcriptionally. The 3' ends of U6 RNA's from various sources may be processed in different ways, or to different extents, depending on the organism or stage of development. The presence of a > p terminus on U6 RNA may influence the activity of U6 RNA either directly during splicing or indirectly by ensuring that the RNA has a defined length or proper conformation (or both).