Musculoskeletal tissue engineering by endogenous stem/progenitor cells.
Musculoskeletal tissue engineering by endogenous stem/progenitor cells.
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内源干/祖细胞的肌肉骨骼组织工程。
DOI：
10.1007/s00441-012-1339-2
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发表时间：
2012
影响因子：
3.6
通讯作者：
Mao,JeremyJ
中科院分区：
文献类型：
--
作者：
Nie,Hemin;Lee,ChangHun;Tan,Jiali;Lu,Chuanyong;Mendelson,Avital;Chen,Mo;Embree,MildredC;Kong,Kimi;Shah,Bhranti;Wang,Shuang;Cho,Shoko;Mao,JeremyJ
从一开始，组织工程就有三个原则：细胞、生物材料支架和信号分子。在这三位一体中，细胞是中心部分，因为细胞是组织的基石。几十年来，细胞疗法一直专注于获取、操纵和输送健康细胞，以治疗疾病或创伤。考虑到细胞传递的复杂性和潜在的高成本，最近人们对组织再生的内源性细胞的兴趣激增。生物材料支架对许多但不是全部的组织工程应用至关重要，并有助于适应或促进多种细胞功能。信号分子可以由移植细胞或内源性细胞产生，也可以通过特异性传递来调节细胞功能。本文综述了最近在组织工程和细胞治疗方面的工作，重点是利用内源性细胞的能力作为组织再生的替代或辅助方法。
From its inception, tissue engineering has had three tenets: cells, biomaterial scaffolds and signaling molecules. Among the triad, cells are the center piece, because cells are the building blocks of tissues. For decades, cell therapies have focused on the procurement, manipulation and delivery of healthy cells for the treatment of diseases or trauma. Given the complexity and potential high cost of cell delivery, there is recent and surging interest to orchestrate endogenous cells for tissue regeneration. Biomaterial scaffolds are vital for many but not all, tissue-engineering applications and serve to accommodate or promote multiple cellular functions. Signaling molecules can be produced by transplanted cells or endogenous cells, or delivered specifically to regulate cell functions. This review highlights recent work in tissue engineering and cell therapies, with a focus on harnessing the capacity of endogenous cells as an alternative or adjunctive approach for tissue regeneration.