Reduced Olfactory Bulb Volume in Adults with a History of Childhood Maltreatment
Reduced Olfactory Bulb Volume in Adults with a History of Childhood Maltreatment
复制标题
DOI：
10.1093/chemse/bjt037
复制
发表时间：
2013-10-01
期刊：
影响因子：
3.5
通讯作者：
Hummel, Thomas
中科院分区：
文献类型：
--
作者：
Croy, Ilona;Negoias, Simona;Hummel, Thomas
人类嗅球是嗅觉通路的第一个中继站，可能在儿童早期具有出生后神经发生的潜力。在动物中，慢性压力会影响OB和嗅觉功能。对于人类，已经表明，重度抑郁症伴随着OB体积减少和嗅觉功能降低。然而，目前尚不清楚儿童发育中的主要压力是否也会影响人类的嗅觉功能和OB体积。对17例有严重儿童期虐待（CM）史的抑郁症患者和10例无严重儿童期虐待史的抑郁症患者进行OB体积测量和嗅觉功能测试。CM患者表现出显着降低的嗅觉阈值和识别能力。CM患者的OB体积显著减少至非CM患者的80%。因此，CM可能会导致出生后神经发生减少，从而影响日后大脑的嗅觉功能。或者，虽然本研究中未分析的其他领域也可能涉及，但在存在不良儿童状况的情况下，OB体积减少可能会增强心理脆弱性。
The human olfactory bulb (OB) is the first relay station of the olfactory pathway and may have the potential for postnatal neurogenesis in early childhood. In animals, chronic stress affects the OB and olfactory functioning. For humans, it has been shown that major depressive disorder is accompanied by reduced OB volume and reduced olfactory function. However, it is not clear if major stress in childhood development also affects olfactory functioning and OB volume in humans. OB volume was measured and olfactory function was tested in 17 depressive patients with and 10 without a history of severe childhood maltreatment (CM). CM patients exhibited a significantly reduced olfactory threshold and identification ability. The OB volume of the CM patients was significantly reduced to 80% of the non-CM patients. In conclusion, postnatal neurogenesis might be by reduced in CM, which may affect olfactory function of the brain in later life. Alternatively, a reduced OB volume may enhance psychological vulnerability in the presence of adverse childhood conditions although other areas not analyzed in this study may also be involved.