Mamu-B*08-positive macaques control simian immunodeficiency virus replication
Mamu-B*08-positive macaques control simian immunodeficiency virus replication
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DOI：
10.1128/jvi.00895-07
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发表时间：
2007-08-01
影响因子：
5.4
通讯作者：
Watkins, David I.
中科院分区：
文献类型：
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作者：
Loffredo, John T.;Maxwell, Jess;Watkins, David I.
某些主要组织相容性复合体（MHC）I类等位基因与人类免疫缺陷病毒和猿猴免疫缺陷病毒（SIV）复制的控制有关。我们设计了序列特异性引物，通过PCR检测恒河猴MHC I类等位基因Mamu-B*08，并筛选了一组SIV感染的猕猴。对196只SIVmac，239只感染的印度恒河猴的分析显示，Mamu-B*08在精英控制者中的代表性显著过高; 38%的精英控制者为Mamu-B*08阳性，而3%的进展者为Mamu-B*08阳性（P = 0.00001）。Mamu-B*08还与慢性期病毒血症降低7.34倍相关（P = 0.002）。因此，Mamu-B*08阳性猕猴可以提供一个很好的模型来了解人类精英控制者中MHC I类等位基因相关的免疫保护和病毒遏制的相关性。
Certain major histocompatibillity complex (MHC) class I allelles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIVmac,239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001). Mamu-B*08 was also associated with a 7.34-fold decrease in chronic phase viremia (P = 0.002). Mamu-B*08-positive macaques may, therefore, provide a good model to understand the correlates of MHC class I allele-associated immune protection and viral containment in human elite controllers.