Psychophysiologic responsivity in posttraumatic stress disorder: Generalized hyperresponsiveness versus trauma specificity
Psychophysiologic responsivity in posttraumatic stress disorder: Generalized hyperresponsiveness versus trauma specificity
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DOI：
10.1016/s0006-3223(98)00182-6
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发表时间：
1998-11-15
影响因子：
10.6
通讯作者：
Liberzon, I
中科院分区：
文献类型：
--
作者：
Casada, JH;Amdur, R;Liberzon, I
背景：临床上，创伤后应激障碍（PTSD）被认为是对各种刺激的过度反应。然而，心理生理学的研究表明，高反应性只刺激，是密切相关的原始traumatic.Methods：这一组实验使用了各种不同的刺激，在创伤相关性，唤醒水平，刺激的感觉方式和程度的认知处理要求评估的生理反应的泛化程度。心率（HR）、额肌电（EMG）和皮肤电（EDG）反应在每个刺激的呈现期间被测量。PTSD受试者（n = 15）的基线EDG升高，对创伤相关刺激的HR和EMG反应增加（战斗声音）与正常对照受试者（n = 11）和战斗对照受试者（n = 10）相比，PTSD和对照组之间没有显着差异，在响应nontrauma-related arousing stimuls.Conclusions：这些结果表明，PTSD受试者的生理高反应性仅限于刺激密切相关的煽动创伤。(C)1998年生物精神病学学会。
Background: Clinically, subjects with posttraumatic stress disorder (PTSD) are viewed as hyperresponsive to a variety of stimuli. Psychophysiologic studies, however have demonstrated hyperresponsiveness only to stimuli that are closely related to the original trauma.Methods: This set of experiments uses a variety of stimuli that vary in trauma-relatedness, arousal level, sensory modality stimulated and degree of cognitive processing demanded to assess the extent of generalization of physiologic responses. Heart rate (HR), frontal electromyogram (EMG), and skin conductance (EDG) responses were measured during presentation of each stimulus.Results: PTSD subjects (n = 15) had an elevated baseline EDG and increased HR and EMG responses to the trauma-related Stimulus (combat sounds) compared to normal control subjects (n = 11) and combat control subjects (n = 10), No significant differences were noted between PTSD and control groups in response to nontrauma-related arousing stimuli.Conclusions: These results suggest that the physiologic hyperresponsivity of PTSD subjects is limited to stimuli closely associated with the inciting trauma. (C) 1998 Society of Biological Psychiatry.