Fast sleep spindle (13-15 Hz) activity correlates with sleep-dependent improvement in visuomotor performance
Fast sleep spindle (13-15 Hz) activity correlates with sleep-dependent improvement in visuomotor performance
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DOI：
10.1093/sleep/31.2.204
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发表时间：
2008-02-01
期刊：
影响因子：
5.6
通讯作者：
Hori, Tadao
中科院分区：
文献类型：
--
作者：
Tamaki, Masako;Matsuoka, Tatsuya;Hori, Tadao
研究目的：记忆增强和快速（13-16 Hz）与缓慢（10-13 Hz）的纺锤波活动在sleeping.Design之间的关系：标准多导睡眠图记录进行了适应，控制nonlearning，和学习的夜晚。自动纺锤波检测和测量被用于视觉确认。设置：参与者睡在个人，温度控制的卧室在睡眠实验室。参与者：12名健康的学生志愿者（9名女性和3名男性，平均年龄：22.3岁）参与了研究。在学习之夜，参与者完成了一个修改版本的镜像跟踪任务的睡眠前学习会话，随后是睡眠后测试会话。没有学习或测试会议进行的适应和nonlearning nights.Measurements和结果：跟踪时间减少了6.4秒（20.6% +/- 2.07%），从presceptible到postsleep会话。学习夜快纺锤波的平均振幅和持续时间均大于非学习夜（均P < 0.05）。技能提高与快梭活动呈正相关（密度[r = 0.76，P < 0.01]，振幅[r = 0.69，P < 0.05]，持续时间[r = 0.67，P < 0.05]）。快速纺锤体活动和镜像跟踪性能之间的显着相关性也很明显的nonlearning夜。镜像跟踪性能和慢纺锤体活动之间没有显着的关系在任何night.Conclusions：丘脑皮质网络的基础上快速纺锤体生成可能有助于或反映可塑性在睡眠过程中。
Study Objectives: The relationship between memory enhancement and fast (13-16 Hz) versus slow (10-13 Hz) spindle activity during sleep was investigated.Design: Standard polysomnographic recordings were conducted during an adaptation, control nonlearning, and learning night. Automatic spindle detection and measurement was utilized with visual confirmation.Setting: Participants slept in individual, temperature-controlled bedrooms in a sleep laboratory.Participants: Twelve healthy student volunteers (9 women and 3 men, mean age: 22.3 years) participated.Interventions: On the learning night, participants completed a presleep learning session on a modified version of mirror-tracing task followed by a postsleep test session. No learning or test sessions were performed on the adaptation and nonlearning nights.Measurements and Results: Tracing time was reduced by 6.4 seconds (20.6% +/- 2.07%) from the presleep to the postsleep session. Mean amplitude and duration of fast spindles was greater on the learning night than on the nonlearning night (both P values < 0.05). Skill improvement and fast-spindle activity were positively correlated (density [r = 0.76, P < 0.01], amplitude [r = 0.69, P < 0.05], and duration [r = 0.67, P < 0.05]). Significant correlations between fast-spindle activity and mirror-tracing performance were also evident for the nonlearning night. There was no significant relationship between mirror-tracing performance and slow-spindle activity on any night.Conclusions: The thalamocortical network underlying fast-spindle generation may contribute to or reflect plasticity during sleep.