Dynamic 18F-FET PET is a powerful imaging biomarker in gadolinium-negative gliomas
Dynamic 18F-FET PET is a powerful imaging biomarker in gadolinium-negative gliomas
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DOI：
10.1093/neuonc/noy098
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发表时间：
2019-02-01
期刊：
影响因子：
15.9
通讯作者：
Thon, Niklas
中科院分区：
文献类型：
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作者：
Kunz, Mathias;Albert, Nathalie Lisa;Thon, Niklas
背景资料。我们旨在阐明动态O-(2-[F-18]-氟乙基)-L酪氨酸(F-18-FET)PET在Gd阴性胶质瘤模型中的定位。在98例Gd阴性的胶质瘤患者中，在F-18-FET PET引导下，每个肿瘤的时间活动曲线(TAC)被定性地分为增加或减少。此外，使用最小达峰时间(TTPmin)测量进行了组后定量分析。从多变量风险模型中获得预后因素，并比较生物医学模型和影像模型的拟合程度。TAC呈均匀增加、混合和均匀降低的分别为51、19和28个肿瘤。混合性TAC瘤表现为TAC增加和减少。相应调整后的5年生存率分别为85%、47%和19%(P<；0.001)。TAC的定性和定量测量高度相关(P<；0.0001)。TTPmin在均匀增加(减少)TAC组中最长(最短)，在混合TAC组中介于两者之间。异柠檬酸脱氢酶(/DH)突变肿瘤的TTPmin较长(P<；0.001)。结果类似地被生物显微镜和成像衍生的模型精确预测。在生理学模型中，世界卫生组织分级(P<；0.0001)和IDH状态(P<；0.001)是生存的预测因素。TAC肿瘤均匀增加(均匀减少)的结果几乎相同，TTP(Min)和Gt；25min(TTPmin 12.5min和
Background. We aimed to elucidate the place of dynamic O-(2-[F-18]-fluoroethyl)-L-tyrosine (F-18-FET) PET in prognostic models of gadolinium (Gd)-negative gliomas.Methods. In 98 patients with Gd-negative gliomas undergoing F-18-FET PET guided biopsy, time activity curves (TACs) of each tumor were qualitatively categorized as either increasing or decreasing. Additionally, post-hoc quantitative analyses were done using minimal time-to-peak (TTPmin) measurements. Prognostic factors were obtained from multivariate hazards models.The fit of the biospecimen- and imaging-derived models was compared.Results. A homogeneous increasing, mixed, and homogeneous decreasing TAC pattern was seen in 51, 19, and 28 tumors, respectively. Mixed TAC tumors exhibited both increasing and decreasing TACs. Corresponding adjusted 5-year survival was 85%, 47%, and 19%, respectively (P < 0.001). Qualitative and quantitative TAC measurements were highly intercorrelated (P< 0.0001).TTPmin was longest (shortest) in the homogeneous increasing (decreasing) TAC group and in between in the mixed TAC group. TTPmin was longer in isocitrate dehydrogenase (/DH)-mutant tumors (P< 0.001). Outcome was similarly precisely predicted by biospecimen- and imaging-derived models. In the biospecimen model, World Health Organization (WHO) grade (P< 0.0001) and IDH status (P< 0.001) were predictors for survival. Outcome of homogeneous increasing (homogeneous decreasing) TAC tumors was nearly identical, with bothTTP(min) > 25 min (TTPmin 12.5 min and