Sustained Negativity for HCV-RNA over 24 or More Months by Long-Term Interferon Therapy Correlates with Eradication of HCV in Patients with Hepatitis C Virus Genotype 1b and High Viral Load
Sustained Negativity for HCV-RNA over 24 or More Months by Long-Term Interferon Therapy Correlates with Eradication of HCV in Patients with Hepatitis C Virus Genotype 1b and High Viral Load
复制标题
通过长期干扰素治疗，HCV-RNA 持续阴性超过 24 个月或更长，与丙型肝炎病毒基因型 1b 和高病毒载量患者的 HCV 根除相关
作者：
Y. Arase;F. Suzuki;A. Tsubota;Yoshiyuki Suzuki;S. Saitoh;M. Kobayashi;N. Akuta;T. Someya;T. Hosaka;M. Kobayashi;H. Sezaki;K. Ikeda;H. Kumada
目的：我们评估长期干扰素（IFN）治疗HCV- rna持续阴性超过24个月或更长时间是否与丙型肝炎病毒基因型1b和高病毒载量患者的HCV根除相关。方法：hcv - 1b基因型、病毒载量超过1 Meq/ml的患者每日给予6 MU天然IFN-α，持续2-8周，随后每周3次，持续16-22周，在IFN给药期间HCV-RNA阴性的患者403例。403例患者中有41例在初始IFN治疗后接受6 MU天然IFN-α治疗，每周3次，持续时间超过18个月（长期IFN组）。302例患者在6个月疗程结束后6个月内未接受任何IFN治疗（6个月IFN组）。持续病毒学反应（SVR）被定义为在IFN治疗完成后3个月和6个月的HCV-RNA阴性。结果：长期ifn组SVR为73.2%(30/41)，6个月ifn组SVR为18.2%（55/302）。多因素分析显示，长期IFN治疗是SVR最显著的影响因素（p < 0.0001）。结论：基因型1b高病毒载量患者长期IFN治疗HCV-RNA持续阴性24个月及以上与SVR相关。
Objective: We assessed whether sustained negativity for HCV-RNA over 24 or more months by long-term interferon (IFN) therapy correlates with eradication of HCV in patients with hepatitis C virus genotype 1b and high viral load or not. Methods: The number of patients with HCV-genotype 1b and high viral load exceeding 1 Meq/ml who received 6 MU of natural IFN-α daily for 2–8 weeks, followed by three times/week for 16–22 weeks and negativity for HCV-RNA during IFN administration was 403. Forty-one of 403 patients received 6 MU of natural IFN-α three times/week for more than 18 months after the initial IFN therapy (long-term-IFN-group). Three hundred and two patients did not receive any IFN treatment for 6 months after the termination of the 6-month course (6-month-IFN-group). Sustained virological response (SVR) was defined as negative HCV-RNA at both 3 and 6 months after the completion of IFN therapy. Results: SVR was noted in 73.2% (30/41) of long-term-IFN-group and 18.2% (55/302) of 6-month-IFN-group. Multivariate analysis showed that long-term IFN therapy was the most significant contributor to SVR (p < 0.0001). Conclusion: Sustained negativity of HCV-RNA for 24 or more months by long-term IFN therapy correlated with SVR in patients with genotype 1b and high viral load.
影响因子：
158.5
作者：
McHutchison, JG;Gordon, SC;Albrecht, JK
通讯作者：
Albrecht, JK