Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)
Ion-exchange resins modified with metal-porphyrin as a catalysis for oxidation of epinephrine (adrenaline)
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DOI：
10.1016/j.catcom.2007.06.005
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发表时间：
2008-02
影响因子：
3.7
通讯作者：
Youji Kitamura;M. Mifune;Tsutomu Takatsuki;T. Iwasaki;Mayumi S. Kawamoto;A. Iwado;M. Chikuma;Yutaka Saito
中科院分区：
文献类型：
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作者：
Youji Kitamura;M. Mifune;Tsutomu Takatsuki;T. Iwasaki;Mayumi S. Kawamoto;A. Iwado;M. Chikuma;Yutaka Saito
为了开发一种可模拟儿茶酚氧化酶和/或儿茶酚胺单胺氧化酶的固体催化剂，考察了金属四(4-磺基苯基)卟啉修饰的离子交换树脂(M-TSPP，其中M为Mn3+、Co3+、Fe3+或Cu2+)对肾上腺素(Adrenaline，Ad)氧化反应的催化活性。在M-TSPP改性树脂(M-TSPPrs)中，Mn-TSPPrex对空气中氧气氧化Ad生成肾上腺素和肾上腺素的催化活性最强。在Ad的水溶液中，Mn-TSPP的催化活性不高。确定了Mn-TSPPr催化氧化反应的最佳条件。在所确定的最佳条件下进行了儿茶酚胺及其相关化合物的氧化反应，结果表明，Mn-TSPP对儿茶酚胺的氧化具有催化作用。
To develop a solid catalyst which can be a model of catechol oxidase and/or catecholamine monoamine oxidase, the ion-exchange resins modified with metal-tetrakis(4-sulfophenyl)porphine (M-TSPP wherein M is Mn3+, Co3+, Fe3+or Cu2+) were examined for a catalytic activity in the oxidative reaction of epinephrine (adrenaline, Ad). Among M-TSPP-modified resins (M-TSPPrs), Mn-TSPPrexhibited the strongest catalytic activity in the oxidation of Ad with O2in the air to adrenochrome and adrenolutin. Mn-TSPP had little catalytic activity in an aqueous solution of Ad. The optimum conditions for the oxidation reaction catalyzed by Mn-TSPPrwere determined. Oxidation of catecholamines and related compounds thereof were conducted under the optimum conditions thus determined, which revealed that Mn-TSPPronly catalyzes oxidation of catecholamines.