Circulating oxidized low-density lipoprotein (LDL) is associated with risk factors of the metabolic syndrome and LDL size in clinically healthy 58-year-old men (AIR study)
Circulating oxidized low-density lipoprotein (LDL) is associated with risk factors of the metabolic syndrome and LDL size in clinically healthy 58-year-old men (AIR study)
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DOI：
10.1046/j.1365-2796.2002.01054.x
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发表时间：
2002-11-01
影响因子：
11.1
通讯作者：
Hulthe, J
中科院分区：
文献类型：
--
作者：
Sigurdardottir, V;Fagerberg, B;Hulthe, J
目标.假设代谢综合征的致动脉粥样硬化作用可能是通过增加小LDL颗粒的发生来介导的，小LDL颗粒容易被修饰为致动脉粥样硬化的氧化LDL（ox-LDL）。本研究的目的是通过检测循环ox-LDL、LDL颗粒大小和代谢综合征之间的关系来验证这一概念。招募了临床健康的58岁男性（n=391）的人群样本。Ox-LDL通过ELISA（特异性单克隆抗体，mAb-4 E6）测量，LDL颗粒大小通过梯度凝胶电泳测量。结果表明，ox-LDL与构成代谢综合征的因素甘油三酯（r=0.43）、血浆胰岛素（r=0.20）、体重指数（r= 0.20）、腰臀比（r=0.21）和高密度脂蛋白（r=-0.24）显著相关（P
Objectives. Hypothetically the atherogenic effect of the metabolic syndrome may be mediated through the increased occurrence of small LDL-particles which are easily modified to atherogenic oxidized LDL (ox-LDL). The aim of this study was to test this concept by examining the association between circulating ox-LDL, LDL-particle size, and the metabolic syndrome.Design and results. A population-based sample of clinically healthy 58-year-old men (n=391) was recruited. Ox-LDL was measured by ELISA (specific monoclonal antibody, mAb-4E6) and LDL-particle size by gradient gel electrophoresis. The results showed that ox-LDL significantly correlated to factors constituting the metabolic syndrome; triglycerides (r=0.43), plasma insulin (r=0.20), body mass index (r=0.20), waist-to-hip ratio (r=0.21) and HDL (r=-0.24); (P