PAProC: a prediction algorithm for proteasomal cleavages available on the WWW
PAProC: a prediction algorithm for proteasomal cleavages available on the WWW
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DOI：
10.1007/s002510100300
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发表时间：
2001-03-01
期刊：
影响因子：
3.2
通讯作者：
Schild, H
中科院分区：
文献类型：
--
作者：
Nussbaum, AK;Kuttler, C;Schild, H
PAProC（蛋白酶体切割预测算法）的第一个版本现在可供公众使用。PAProC是基于实验切割数据的人和酵母蛋白酶体切割的预测工具。这将是特别有用的免疫学家工作的抗原处理和预测的主要组织相容性复合物I类分子（MHC I）配体和细胞毒性T淋巴细胞（CTL）表位。同样，在疾病中蛋白酶体蛋白降解的情况下，PAProC可用于评估疾病相关蛋白的一般可切割性。在其网站（http：//www.example.com）上，为用户提供了背景信息和超链接（例如，www.paproc.de到SYFPEG1，用于预测MHC I配体的数据库）。
The first version of PAProC (Prediction Algorithm for Proteasomal Cleavages) is now available to the general public. PAProC is a prediction tool for cleavages by human and yeast proteasomes, based on experimental cleavage data. It will be particularly useful for immunologists working on antigen processing and the prediction of major histocompatibility complex class I molecule (MHC I) ligands and cytotoxic T-lymphocyte (CTL) epitopes. Likewise, in cases in which proteasomal protein degradation has been indicated in disease, PAProC can be used to assess the general cleavability of disease-linked proteins. On its web site (http://www.paproc.de), background information and hyperlinks are provided for the user (e.g., to SYFPEITHI, the database for the prediction of MHC I ligands).