Hepatic fibrosis-Overview
Hepatic fibrosis-Overview
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DOI：
10.1016/j.tox.2008.06.013
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发表时间：
2008-12-30
期刊：
影响因子：
4.5
通讯作者：
Friedman, Scott L.
中科院分区：
文献类型：
--
作者：
Friedman, Scott L.
在过去的二十年中，肝纤维化的研究或针对慢性肝损伤造成了疤痕。澄清疤痕的细胞来源，以及肝星状细胞的出现不仅是纤维纤维细胞类型，而且是关键的免疫调节和稳态调节剂，也是最显着的进步。肝星状细胞的激活仍然是纤维化中的一个中心事件，并补充了基质产生的细胞的其他证据，包括骨髓，门户成纤维细胞，以及来自肝细胞和胆管细胞的上皮间质转变。越来越多的细胞因子及其受体和炎症细胞亚群进一步扩大了我们对这一动态过程的了解。总的来说，这些发现为持续阐明潜在机制的基础奠定了基础，更重要的是实施基于理性的方法来限制纤维化，加速修复并增强慢性肝病患者的肝脏再生。 （c）2008 Elsevier Ireland Ltd.保留所有权利。
The study of hepatic fibrosis, or scarring in response to chronic liver injury, has witnessed tremendous progress in the past two decades. Clarification of the cellular sources of scar, and emergence of hepatic stellate cells not only as a fibrogenic cell type, but also as a critical immunomodulatory and homeostatic regulator are among the most salient advances. Activation of hepatic stellate cells remains a central event in fibrosis, complemented by evidence of additional sources of matrix-producing cells including bone marrow, portal fibroblasts, and epithelial-mesenchymal transition from both hepatocytes and cholangiocytes. A growing range of cytokines and their receptors and inflammatory cell subsets have further expanded our knowledge about this dynamic process. Collectively, these findings have laid the foundation for continued elucidation of underlying mechanisms, and more importantly for the implementation of rationally based approaches to limit fibrosis, accelerate repair and enhance liver regeneration in patients with chronic liver disease. (C) 2008 Elsevier Ireland Ltd. All rights reserved.