A PHYSIOLOGICAL AND STRUCTURAL STUDY OF NEURON TYPES IN THE COCHLEAR NUCLEUS .1. INTRACELLULAR RESPONSES TO ACOUSTIC STIMULATION AND CURRENT INJECTION
A PHYSIOLOGICAL AND STRUCTURAL STUDY OF NEURON TYPES IN THE COCHLEAR NUCLEUS .1. INTRACELLULAR RESPONSES TO ACOUSTIC STIMULATION AND CURRENT INJECTION
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DOI：
10.1002/cne.903460102
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发表时间：
1994-08-01
影响因子：
2.5
通讯作者：
MOREST, DK
中科院分区：
文献类型：
--
作者：
FENG, JJ;KUWADA, S;MOREST, DK
耳蜗核神经元在受到音调刺激时，其放电模式不同。它们在体外对去极化电流注入的反应也不同。我们从沙鼠和灰鼠耳蜗核的神经元进行细胞内记录。比较了相同神经元对音调和去极化电流的反应。三个类别的反应模式的音调进行了观察：斩波器，初级样，和发病。斩波神经元反应定期间隔动作电位的刺激音调和注射去极化电流。它们的反应率随着电流水平的增加而上升到最大值，这与阈上音引起的反应率相当。这些观察结果表明，这些神经元的规律性和最大放电率是由电压依赖性膜特性。初级样神经元以不规则间隔的动作电位对音调作出反应。向这些神经元中注入去极化电流在电流开始时产生单个动作电位，随后可以产生一些不规则间隔的动作电位。答复率与目前的水平关系不大。这些数据表明，初级样神经元的膜特性不同于斩波神经元。发病神经元产生的动作电位，只有在开始的刺激的音调和去极化电流，即使有一个持续的去极化整个持续时间的音调。研究结果表明，耳蜗核神经元具有不同的膜特性，这些特性可能在神经元对声刺激的时间响应模式中起关键作用。(C)1994 Wiley-Liss，Inc.
Neurons in the cochlear nucleus differ in their discharge patterns when stimulated by tones. They also differ in their responses to depolarizing current injection in vitro. We made intracellular recordings from neurons in the cochlear nucleus of gerbils and chinchillas. The responses to tones and to depolarizing current were compared for the same neurons. Three categories of response patterns to tones were observed: chopper, primary-like, and onset. Chopper neurons responded with regularly spaced action potentials to stimulation with tones and to injections of depolarizing current. Their response rate rose with increasing levels of current to a maximum, which was comparable to that evoked by suprathreshold tones. These observations suggest that the regularity and maximal firing rate of these neurons are determined by voltage-dependent membrane properties. Primary-like neurons responded with irregularly spaced action potentials to tones. Injection of depolarizing current into these neurons produced a single action potential at current onset, which could be followed by a few irregularly spaced action potentials. The response rate showed little relation to current level. These data suggest that the membrane characteristics of primary-like neurons are different from those of chopper neurons. Onset neurons produced action potentials only at the beginning of the stimulus for both tones and depolarizing current, even though there was a sustained depolarization throughout the duration of the tone. The findings suggest that cochlear nucleus neurons have different membrane properties and that these properties may play a critical role in a neuron's temporal response pattern to acoustic stimulation. (C) 1994 Wiley-Liss, Inc.