Novel generations of influenza vaccines
Novel generations of influenza vaccines
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DOI：
10.1016/s0264-410x(03)00074-4
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发表时间：
2003-05-01
期刊：
影响因子：
5.5
通讯作者：
Greenberg, H
中科院分区：
文献类型：
--
作者：
Kemble, G;Greenberg, H
目前正在采取几种策略来提高每年使用的流感疫苗的质量和数量，包括提高目前许可的灭活疫苗的免疫原性、将灭活疫苗直接递送至鼻粘膜、使用细胞系生产病毒以及使用减毒活疫苗。此外，现代分子生物学技术正被用于创建和评估新的疫苗方法。本报告将简要审查这些不同的战略，并概述与之相关的一些潜在优势和挑战。(C)2003爱思唯尔科技有限公司版权所有。
Several strategies are being pursued to increase the quality and quantity of influenza vaccines that are used on an annual basis including increasing the immunogenicity of currently licensed inactivated vaccines, delivery of inactive vaccines directly to the nasal mucosa, the use of cell lines for virus production and the use of live, attenuated vaccines. In addition, modern molecular biological techniques are being used to create and evaluate new vaccine approaches. This report will briefly review these different strategies and outline some of the potential advantages and challenges associated with them. (C) 2003 Elsevier Science Ltd. All rights reserved.