CYTOMEGALO-VIRUS RETINITIS IN IMMUNOSUPPRESSED HOSTS .2. OCULAR MANIFESTATIONS
CYTOMEGALO-VIRUS RETINITIS IN IMMUNOSUPPRESSED HOSTS .2. OCULAR MANIFESTATIONS
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DOI：
10.7326/0003-4819-93-5-664
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发表时间：
1980-01-01
影响因子：
39.2
通讯作者：
MERIGAN, TC
中科院分区：
文献类型：
--
作者：
EGBERT, PR;POLLARD, RB;MERIGAN, TC
本文观察了14例免疫抑制患者21眼巨细胞病毒（CMV）视网膜炎的病程。在2例患者中，弓形虫和念珠菌似乎同时引起视网膜疾病。对7例患者的10只眼进行了尸检。在最初的表现，视网膜炎往往是无症状的，诊断在常规检查。检眼镜检查图像为巨细胞病毒的特征;早期病变为视网膜坏死的小的不透明、白色颗粒状区域，以离心、刷火样方式扩散1-8个月。随着病情的发展，出现了血管鞘和血管扩张。在两名患者中，新的视网膜炎病灶远离原始病变。4周至4个月。（平均，10周）从最广泛的疾病到完全消退。活动性疾病消退后，1/2患眼的最终视力下降，留下了轻微的视网膜瘢痕。反复检眼镜检查可以帮助早期诊断CMV视网膜炎，并确定哪些人最有可能视力丧失。
The course of cytomegalovirus (CMV) retinitis in 21 eyes of 14 immunosuppressed patients was observed. In 2 patients Toxoplasma and Candida appeared to be causing retinal disease simultaneously. Post-mortem examination was done on 10 eyes from 7 patients. At initial presentation, the retinitis was often asymptomatic and diagnosed during routine examination. The ophthalmoscopic picture was characteristic of cytomegalovirus; the early lesion was a small opaque, white granular area of retinal necrosis that spread in a centrifugal, brush-fire-like manner over 1-8 mo. Vessel sheating and hemorrhages appeared as the disease progressed. In two patients new foci of retinitis developed remote from the original lesion. Four wk to 4 mo. (average, 10 wk) elapsed from the most extensive disease to total resolution. Resolution of active disease left a subtle retinal scar and final visual acuity was reduced in 1/2 the eyes. Repeated ophthalmoscopic examinations can aid in early diagnosis of CMV retinitis and in ascertaining which persons are most at risk for visual loss.