Cognitive functioning in children with early onset type 1 diabetes and severe hypoglycemia
Cognitive functioning in children with early onset type 1 diabetes and severe hypoglycemia
复制标题
DOI：
10.1016/j.jpeds.2005.06.010
复制
发表时间：
2005-11-01
影响因子：
5.1
通讯作者：
Jones, TW
中科院分区：
文献类型：
--
作者：
Strudwick, SK;Carne, C;Jones, TW
目的探讨早发1型糖尿病（T1DM）幼儿严重低血糖是否与随后的认知状态异常相关。研究设计招募来自T1DM儿童和青少年的大型人群数据库。患有早发性 T1DM（< 6 岁）的儿童和青少年有资格参加该研究。将具有前瞻性记录的癫痫或昏迷病史的糖尿病个体 (n = 41) 与没有严重低血糖事件病史的同龄人 (n = 43) 进行比较。学习和记忆的综合测试组与智力和行为测量一起使用。结果在智力、记忆或行为测量上没有显示显着的组间差异。同样，那些有早期首次癫痫发作史的参与者与没有癫痫发作的同龄人没有差异。考虑到对海马功能受损的潜在敏感性，所检查的备忘录子测试没有显着的组间差异。 结论 该队列没有明确的证据表明癫痫发作或昏迷发作，即使发生在儿童早期，也会导致广泛的认知功能障碍，也没有证据表明早发性 T1DM 儿童和青少年在测试时存在特定的记忆困难。
Objective To investigate whether severe hypocemia in young children with early-onset type 1 diabetes (T1DM) is associated with subsequent abnormalities in cognitive status.Study design Recruitment was from a large population-based database of children and adolescents with T1DM. Children and adolescents with early-onset T1DM (< 6 years) were eligible for the study. Diabetic individuals (n = 41) with a prospectively documented history of seizure or coma were compared with peers with no history of severe hypoglycemic events (n = 43). A comprehensive test battery of learning and memory was used together with intellectual and behavioral measures.Results No significant group differences were revealed on the intellectual, memory, or behavioral measures. Similarly, those participants with a history of early first seizure did not differ from their peers with no seizures. There were no significant group differences on the memo subtests that were examined given their potential sensitivity to compromised hippocampal function.Conclusions There was no clear evidence from this cohort that episodes of seizure or coma, even those occurring in very early childhood, resulted in broad cognitive dysfunction, nor was there evidence of specific memory difficulties at the time of testing in children and adolescents with early-onset T1DM.