Measurement of retinal nerve fiber layer thickness in eyes with optic disc swelling by using scanning laser polarimetry and optical coherence tomography.
Measurement of retinal nerve fiber layer thickness in eyes with optic disc swelling by using scanning laser polarimetry and optical coherence tomography.
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DOI：
10.2147/opth.s46769
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Yoshimura N
中科院分区：
文献类型：
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作者：
Hata M;Miyamoto K;Oishi A;Kimura Y;Nakagawa S;Horii T;Yoshimura N
应用扫描激光偏振仪(SLP)和光谱域光学相干断层扫描(OCT)对不同病因的视盘肿胀患者的视网膜神经纤维层厚度(RNFLT)进行比较。47例视盘肿胀患者参加了横断面研究。对京都大学医院神经眼科门诊19眼乳头水肿(PE)、10眼视神经炎(ON)和18眼非动脉炎性前部缺血性视神经病变(NAION)分别进行了GDX-SLP(增强型角膜补偿)和Spectralis光谱域OCT检查。研究不同病因间SLP(SLP-RNFLT)和OCT(OCT-RNFLT)测量的差异。在PE、ON和NAION患者之间，OCT-RNFLT的平均值没有统计学差异。NAION患者平均SLP-RNFLT小于PE(P<；0.01)或ON患者(P=0.02)。当比较各视网膜象限的RNFlt时，在OCT上没有发现病因的差异，但在SLP上，NAION的上象限比PE(P<；0.001)或PE(P=0.001)更薄。与SLP-RNFLT的年龄调整标准数据相比，PE(P<；0.01)和ON(P<；0.01)患者的SLP-RNFLT平均值更大。NAION患者上位SLP-RNFLT较小(P=0.026)。NAION组SLP-RNFLT与OCT-RNFLT比值明显小于PE组(P=0.001)。在RNFL增厚的情况下，尽管PE和眼的光延迟增加，SLP显示NAION眼的延迟较小，可能与缺血性轴突丢失有关。
The retinal nerve fiber layer thickness (RNFLT) in patients with optic disc swelling of different etiologies was compared using scanning laser polarimetry (SLP) and spectral-domain optical coherence tomography (OCT). Forty-seven patients with optic disc swelling participated in the cross-sectional study. Both GDx SLP (enhanced corneal compensation) and Spectralis spectral-domain OCT measurements of RNFLT were made in 19 eyes with papilledema (PE), ten eyes with optic neuritis (ON), and 18 eyes with nonarteritic anterior ischemic optic neuropathy (NAION) at the neuro-ophthalmology clinic at Kyoto University Hospital. Differences in SLP (SLP-RNFLT) and OCT (OCT-RNFLT) measurements among different etiologies were investigated. No statistical differences in average OCT-RNFLT among PE, ON, and NAION patients were noted. Average SLP-RNFLT in NAION patients was smaller than in PE (P<0.01) or ON (P=0.02) patients. When RNFLT in each retinal quadrant was compared, no difference among etiologies was noted on OCT, but on SLP, the superior quadrant was thinner in NAION than in PE (P<0.001) or ON (P=0.001) patients. Compared with age-adjusted normative data of SLP-RNFLT, average SLP-RNFLT in PE (P<0.01) and ON (P<0.01) patients was greater. Superior SLP-RNFLT in NAION patients was smaller (P=0.026). The ratio of average SLP-RNFLT to average OCT-RNFLT was smaller in NAION than in PE (P=0.001) patients. In the setting of RNFL thickening, despite increased light retardance in PE and ON eyes, SLP revealed that NAION eyes have less retardance, possibly associated with ischemic axonal loss.