Transcription Blockage Leads to New Beginnings.
Transcription Blockage Leads to New Beginnings.
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DOI：
10.3390/biom5031600
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发表时间：
2015-07-21
期刊：
影响因子：
5.5
通讯作者：
Ljungman M
中科院分区：
文献类型：
--
作者：
Andrade-Lima LC;Veloso A;Ljungman M
Environmental agents are constantly challenging cells by damaging DNA, leading to the blockage of transcription elongation. How do cells deal with transcription-blockage and how is transcription restarted after the blocking lesions are removed? Here we review the processes responsible for the removal of transcription-blocking lesions, as well as mechanisms of transcription restart. We also discuss recent data suggesting that blocked RNA polymerases may not resume transcription from the site of the lesion following its removal but, rather, are forced to start over from the beginning of genes.
