THE CONFORMATIONS OF OLIGOSACCHARIDES RELATED TO THE ABH AND LEWIS HUMAN-BLOOD GROUP DETERMINANTS
THE CONFORMATIONS OF OLIGOSACCHARIDES RELATED TO THE ABH AND LEWIS HUMAN-BLOOD GROUP DETERMINANTS
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DOI：
10.1139/v80-098
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发表时间：
1980-01-01
影响因子：
1.1
通讯作者：
RAO, VS
中科院分区：
文献类型：
--
作者：
LEMIEUX, RU;BOCK, K;RAO, VS
NMR 性质与合成寡糖的构象预期非常一致，这些构象是通过硬球模型预测的，并考虑了外型异头效应的重要贡献。这些研究涉及 .beta 的比较。 DGal(1.fwdarw.3).beta。 DGlcNAc（1 型）和 .beta。 DGal(1.fwdarw.4).beta。 DGlcNAc（2 型）二糖结构主要基于 13Cmr [13C 磁共振]，并检查计算的构象与源自 1 型核心二糖的人类血型决定因素的 1Hmr 和 13Cmr 参数之间的关系。所检查的结构包括 ABH 和 Lewis 抗原决定簇的二糖、三糖和四糖。注意到某些免疫学构象关系。
NMR properties were in good accord with those that are expected for synthetic oligosaccharides in the conformations which are predicted by hard-sphere modelling and taking into consideration the important contribution by the exo-anomeric effect. The studies involve a comparison of the .beta. DGal(1 .fwdarw. 3).beta. DGlcNAc (Type 1) and .beta. DGal(1 .fwdarw. 4).beta. DGlcNAc (Type 2) disaccharide structures based mainly on 13Cmr [13C magnetic resonance] and an examination of the relationships between the calculated conformations and 1Hmr and 13Cmr parameters for human blood group determinants which are derived from the Type 1 core disaccharide. Among the structures examined were the di-, tri- and tetrasaccharides for the ABH and Lewis antigenic determinants. Certain immunological-conformational relationships were noted.