Interaction of COMT rs4680 and BDNF rs6265 polymorphisms on functional connectivity density of the left frontal eye field in healthy young adults
Interaction of COMT rs4680 and BDNF rs6265 polymorphisms on functional connectivity density of the left frontal eye field in healthy young adults
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DOI：
10.1002/hbm.23187
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发表时间：
2016-03
影响因子：
4.8
通讯作者：
Wei Li;Bing Liu;Jiayuan Xu;T. Jiang;Chunshui Yu
中科院分区：
文献类型：
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作者：
Wei Li;Bing Liu;Jiayuan Xu;T. Jiang;Chunshui Yu
作为大脑中多巴胺可获得性和释放的调节器，COMT和BDNF基因的多态已经证明了对人类认知的相互作用；然而，其潜在的神经机制在很大程度上仍然不清楚。在这项研究中，我们旨在研究COMT rs4680和BDNF rs6265的相互作用对265名健康青年大脑整体功能连接密度(GFCD)的影响。我们发现在左侧额叶视野的gFCD上存在显著的COMT和BDNF的相互作用，显示出一种受推测的多巴胺信号的倒U型调制。在使用其他四个连接阈值的gFCD分析中，这一发现一直重复。我们的发现揭示了在左侧FEF的FCD上存在COMT和BDNF的相互作用，这可能有助于理解COMT和BDNF相互作用对FEF相关认知功能的神经机制。Hum Brain Mapp 37：2468-2478,2016。©2016 Wiley期刊，Inc.
As modulators of dopamine availability and release in the brain, COMT and BDNF polymorphisms have demonstrated interactions on human cognition; however, the underlying neural mechanisms remain largely unknown. In this study, we aimed to investigate the interactions of COMT rs4680 and BDNF rs6265 on global functional connectivity density (gFCD) of the brain in 265 healthy young subjects. We found a significant COMT × BDNF interaction on the gFCD in the left frontal eye field (FEF), showing an inverted U‐shape modulation by the presumed dopamine signaling. This finding was consistently repeated in the gFCD analyses using other four connection thresholds. Our findings reveal a COMT × BDNF interaction on the FCD in the left FEF, which may be helpful for understanding the neural mechanisms of the COMT × BDNF interactions on the FEF‐related cognitive functions. Hum Brain Mapp 37:2468–2478, 2016. © 2016 Wiley Periodicals, Inc.