PRESERVED CONFIGURAL LEARNING AND SPATIAL-LEARNING IMPAIRMENT IN RATS WITH HIPPOCAMPAL DAMAGE
PRESERVED CONFIGURAL LEARNING AND SPATIAL-LEARNING IMPAIRMENT IN RATS WITH HIPPOCAMPAL DAMAGE
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DOI：
10.1002/hipo.450020111
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发表时间：
1992-01-01
期刊：
影响因子：
3.5
通讯作者：
HOLLAND, PC
中科院分区：
文献类型：
--
作者：
GALLAGHER, M;HOLLAND, PC
本研究比较了大鼠海马神经毒性损伤对两种行为任务的影响，一种是空间学习测试，另一种是通过形成非空间图形联想获得的操作性辨别任务。海马的损伤与鹅膏蕈氨酸的显微注射。术后恢复后，首先训练大鼠使用远端空间线索在水迷宫中定位一个封闭的逃避平台。大鼠也在具有可见的逃避平台的迷宫装置中在空间信息与表现无关的条件下训练，即，线索学习在操作性任务中，同样的大鼠随后接受包括同时的特征阳性和特征阴性成分的辨别训练（试验类型XA+、A-、X B-、B+）。在完成该非空间性迷宫学习任务后，大鼠在水迷宫中接受额外的训练，使用新的平台位置进行空间学习。在某种程度上，在迷宫和操作任务中的熟练表现取决于海马体的共同功能，即，海马损伤对两项任务的表现同样有害。与此预期相反，损伤大鼠的空间学习能力严重受损，但很容易获得的操作性歧视，甚至表现出一些证据的增强性能在这个非空间图形学习任务。损伤大鼠在水迷宫提示训练中的表现也相对于对照组有所增强。这些结果表明，海马损伤大鼠的空间学习缺陷并不一定发生在一般的神经学习障碍的情况下，如Sutherland和Rudy最初提出的那样（1989，Psychobiology 17：129-144）。
This study was undertaken to compare the effect of hippocampal neurotoxic lesions in rats on two behavioral tasks, one a test of spatial learning, and the other an operant discrimination task that is acquired by forming nonspatial configural associations. Lesions of the hippocampus were made with microinjections of ibotenic acid. After postoperative recovery, rats were trained initially to locate a camouflaged escape platform in a water maze using distal spatial cues. Rats also were trained in the maze apparatus with a visible escape platform under conditions in which spatial information was made irrelevant to performance, i.e., cue learning. In an operant task, the same rats were then trained on a discrimination that included simultaneous feature positive and feature negative components (trial types XA+, A-, XB-, B+). After completion of this nonspatial configural learning task, rats received additional training in the water maze using a new platform location for spatial learning. To the extent that proficient performance in both the maze and operant tasks depends on a common function of the hippocampus, i.e., configural learning, the expectation was that hippocampal lesions would prove equally detrimental to performance in both tasks. Contrary to this expectation, lesioned rats were severely impaired in spatial learning but readily acquired the operant discrimination, even exhibiting some evidence of enhanced performance on this nonspatial configural learning task. Performance of the lesioned rats during cue training in the water maze was also enhanced relative to the control group. These results demonstrate that a spatial learning deficit in rats with hippocampal damage does not necessarily occur in the setting of a general configural learning impairment, as originally suggested by Sutherland and Rudy (1989, Psychobiology 17:129-144).