Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence
Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence
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DOI：
10.4049/jimmunol.174.2.1037
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发表时间：
2005-01-15
影响因子：
4.4
通讯作者：
Pantaleo, G
中科院分区：
文献类型：
--
作者：
Harari, A;Vallelian, F;Pantaleo, G
记忆 CD4 T 细胞反应在功能和表型上存在异质性。在本研究中，在不同的 Ag 特异性免疫反应模型中分析了记忆 CD4 T 细胞反应，这些模型的 Ag 暴露和/或持久性不同。比较了破伤风类毒素、HSV、EBV、CMV 和 HIV-1 的 Ag 特异性 CD4 T 细胞反应。观察到三种不同的 T 细胞反应模式。占主导地位的单一 IL-2 CD4 T 细胞反应与 Ag 可以被清除的模型相关。多功能（单一 IL-2 加 IL-2/IFN-gamma 加单一 IFN-gamma）CD4 T 细胞反应与 Ag 持久性和低 Ag 水平相关。占主导地位的单一 IFN-γ CD4 T 细胞反应与 Ag 持久性和高 Ag 水平模型相关。获得的结果支持了以下假设：观察到的不同模式很大程度上受到不同银暴露和持久性条件的影响。
Memory CD4 T cell responses are functionally and phenotypically heterogeneous. In the present study, memory CD4 T cell responses were analyzed in different models of Ag-specific immune responses differing on Ag exposure and/or persistence. Ag-specific CD4 T cell responses for tetanus toxoid, HSV, EBV, CMV, and HIV-1 were compared. Three distinct patterns of T cell response were observed. A dominant single IL-2 CD4 T cell response was associated with the model in which the Ag can be cleared. Polyfunctional (single IL-2 plus IL-2/IFN-gamma plus single IFN-gamma) CD4 T cell responses were associated with Ag persistence and low Ag levels. A dominant single IFN-gamma CD4 T cell response was associated with the model of Ag persistence and high Ag levels. The results obtained supported the hypothesis that the different patterns observed were substantially influenced by different conditions of Ag exposure and persistence.