Deep Brain Stimulation for Depression Informed by Intracranial Recordings.
Deep Brain Stimulation for Depression Informed by Intracranial Recordings.
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脑深部电刺激治疗抑郁症的颅内记录。
DOI：
10.1016/j.biopsych.2021.11.007
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发表时间：
2022-08-01
影响因子：
10.6
通讯作者：
中科院分区：
文献类型：
--
作者：
The success of deep brain stimulation (DBS) for treating Parkinson’s disease has led to its application to several other disorders, including treatment-resistant depression (TRD). Results with DBS for TRD have been heterogeneous, with inconsistencies largely driven by incomplete understanding of the brain networks regulating mood, especially on an individual basis. We report results from the first subject treated with DBS for TRD using an approach that incorporates intracranial recordings to personalize understanding of network behavior and its response to stimulation. These recordings enabled calculation of individually optimized DBS stimulation parameters using a novel “inverse solution” approach. In the ensuing double-blind randomized phase incorporating these bespoke parameter sets, DBS led to remission of symptoms and dramatic improvement in quality of life. Results from this initial case demonstrate the feasibility of this personalized platform, which may be used to improve surgical neuromodulation for a vast array of neurological and psychiatric disorders.
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影响因子：
3.6
作者：
Jobst, Barbara C.;Bartolomei, Fabrice;Gotman, Jean
通讯作者：
Gotman, Jean
影响因子：
25.8
作者：
Bergfeld, Isidoor O.;Mantione, Mariska;Denys, Damiaan
通讯作者：
Denys, Damiaan
影响因子：
11
作者：
Riva-Posse P;Choi KS;Holtzheimer PE;Crowell AL;Garlow SJ;Rajendra JK;McIntyre CC;Gross RE;Mayberg HS
通讯作者：
Mayberg HS
影响因子：
3.3
作者：
Sanger, Terence D.;Liker, Mark;Robison, Aaron
通讯作者：
Robison, Aaron
影响因子：
48
作者：
Vitek, Jerrold L.;Jain, Roshini;Starr, Philip A.
通讯作者：
Starr, Philip A.