Serological testing for herpes simplex virus (HSV)-1 and HSV-2 infection
Serological testing for herpes simplex virus (HSV)-1 and HSV-2 infection
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DOI：
10.1086/342104
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发表时间：
2002-10-15
影响因子：
11.8
通讯作者：
Ashley-Morrow, R
中科院分区：
文献类型：
--
作者：
Wald, A;Ashley-Morrow, R
可以准确区分HSV-1和HSV-2的单纯疱疹病毒（HSV）血清学检测现已上市。这些测试检测HSV糖蛋白G-1和G-2的抗体，引起类型特异性抗体反应。Focus Technologies生产HerpeSelect-1和HerpeSelect-2酶联免疫吸附试验以及HSV-1和HSV-2 HerpeSelect 1/2免疫印迹。诊断学公司已经销售了POCkit-HSV-2，这是一种HSV-2的即时检测方法，可以在诊所对手指针刺的血液进行检测。这些测试可用于确认生殖器疱疹的诊断，建立HSV感染的诊断与非典型投诉的患者，确定无症状携带者，并确定在获得HSV的风险的人。使用这些测试的潜在环境包括性传播疾病诊所，产前诊所和护理人类免疫缺陷病毒患者的诊所。患者对HSV血清学检测的兴趣似乎很高。
Serological tests for herpes simplex virus (HSV) that can accurately distinguish between HSV-1 and HSV-2 are now commercially available. These tests detect antibodies to HSV glycoproteins G-1 and G-2, which evoke a type-specific antibody response. Focus Technologies produces the HerpeSelect-1 and HerpeSelect-2 enzyme-linked immunosorbent assay tests and the HSV-1 and HSV-2 HerpeSelect1/2 Immunoblot. Diagnology has marketed POCkit-HSV-2, a point-of-care test for HSV-2 that allows blood from a finger stick to be tested in a clinic. These tests can be used to confirm a genital herpes diagnosis, establish diagnosis of HSV infection in patients with atypical complaints, identify asymptomatic carriers, and identify persons at risk for acquiring HSV. Potential settings for use of these tests include sexually transmitted disease clinics, prenatal clinics, and clinics that care for patients with human immunodeficiency virus. Patient interest in HSV serological tests appears high.