Effect of a phytoestrogen food supplement on reproductive health in normal males.
Effect of a phytoestrogen food supplement on reproductive health in normal males.
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DOI：
10.1042/cs1000613
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发表时间：
2001-06
期刊：
影响因子：
6
通讯作者：
Julie H. Mitchell;E. Cawood;D. Kinniburgh;Anne Provan;A. Collins;D. Irvine
中科院分区：
文献类型：
--
作者：
Julie H. Mitchell;E. Cawood;D. Kinniburgh;Anne Provan;A. Collins;D. Irvine
动物研究和人类干预试验已经证明植物雌激素具有化学预防癌症的特性，植物雌激素补充剂现在可以在“非处方药”中广泛使用。然而，食用富含植物雌激素的饮食可能会导致某些动物的生育能力受损和生殖道疾病，而近几十年来人类精子质量的明显下降可能与环境内分泌干扰物暴露的增加有关。本研究确定了短期植物雌激素补充剂对人类男性精液质量以及血清性类固醇和促性腺激素水平的影响。健康志愿者连续两个月每天服用含有 40 毫克异黄酮的补充剂，并在补充剂前 2 个月和补充剂后 4 个月每月捐献血液和精液样本。分析精液样本的射精量、精子浓度、精子总数、活力和形态。分析血样的性激素和促性腺激素水平以及植物雌激素浓度，并使用睾丸计测量睾丸体积。植物雌激素补充剂将血浆染料木黄酮和大豆黄酮浓度增加至约 10%。分别为1μM和0.5μM；然而，在研究期间，对内分泌测量、睾丸体积或精液参数没有观察到影响。这是第一项研究植物雌激素补充剂对男性生殖健康影响的研究。我们的结论是，消耗的植物雌激素剂量对精液质量没有影响。
Animal studies and human intervention trials have demonstrated the cancer chemopreventive properties of plant phytoestrogens, and phytoestrogen supplements are now widely available 'over-the-counter'. However, consumption of phytoestrogen-rich diets can cause impaired fertility and reproductive tract disorders in some animals and the apparent decline in human sperm quality over recent decades may be related to increased exposure to environmental endocrine disruptors. The present study determines the effects of a short-term phytoestrogen supplement on semen quality and serum sex steroid and gonadotrophin levels in human males. Healthy volunteers took a supplement containing 40 mg of isoflavones daily for 2 months and donated blood and semen samples monthly for 2 months before and 4 months after supplementation. Semen samples were analysed for ejaculate volume, sperm concentration, total sperm count, motility and morphology. Blood samples were analysed for sex hormone and gonadotrophin levels and phytoestrogen concentrations, and testicular volume was measured using an orchidometer. The phytoestrogen supplement increased plasma genistein and daidzein concentrations to approx. 1 microM and 0.5 microM respectively; yet, there was no observable effect on endocrine measurements, testicular volume or semen parameters over the study period. This is the first study to examine the effects of a phytoestrogen supplement on reproductive health in males. We conclude that the phytoestrogen dose consumed had no effect on semen quality.