Detecting respiratory viruses in children with protracted bacterial bronchitis
Detecting respiratory viruses in children with protracted bacterial bronchitis
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检测患有迁延性细菌性支气管炎的儿童的呼吸道病毒
DOI：
10.1016/j.rmed.2019.04.003
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发表时间：
2019-05-01
影响因子：
4.3
通讯作者：
Shao, Xuejun
中科院分区：
文献类型：
--
作者：
Wang, Yuqing;Hao, Chuangli;Shao, Xuejun
目的：方法：回顾性分析2014年1月至2017年12月收治的68例PBB患儿支气管-肺泡灌洗液（BALF）中呼吸道病毒的检测情况。35例持续性肺炎或慢性肺炎患儿作为对照组。结果：PBB患儿BALF细菌检出率为61.8%，明显高于对照组的20%（P < 0.001）; PBB患儿BALF中病毒检出率为23.5%，其中鼻病毒6例（8.8%），副流感病毒3型4例（5.9%），博卡病毒2例（2.9%），呼吸道合胞病毒1型2例（2.9%），人偏头痛病毒1例（1.5%），甲型流感病毒1例（1.5%）。对照组检出病毒10例（28.6%），其中呼吸道合胞病毒3例（8.6%），鼻病毒3例（8.6%），博卡病毒2例（5.7%）。两组病毒检出率差异无统计学意义（P=0.577）。结论：PBB患儿BALF中可检出呼吸道病毒，但无证据表明PBB是由病毒引起的。
Objective: This study is to investigate the status and clinical significance of respiratory viruses in bronch-oalveolar lavage fluid (BALF) of children with PBB.Methods: Sixty-eight children with PBB aged from 3 months to 5 years were enrolled and retrospectively reviewed from January 2014 to December 2017. Thirty-five children with persistent pneumonia or chronic pneumonia were matched as controls. Bronchoalveolar lavage fluid samples were collected for respiratory virus detection and bacterial culture.Results: The detection rate of bacteria in BALF of children with PBB was 61.8%, which was significantly higher than that of control group (20%) (P < 0.001). The detection rate of virus in BALF of children with PBB was 23.5%, including 6 (8.8%) of rhinovirus, 4 (5.9%) of parainfluenza virus type 3, 2(2.9%) of bocavirus, 2 (2.9%) of respiratory syncytial virus 1 (1.5%) of human metapneumonia virus and 1 (1.5%) of influenza virus A. 10 cases (28.6%) of virus were detected in the control group, including 3 (8.6%) respiratory syncytial virus, 3 (8.6%) rhinovirus and 2 (5.7%) bocavirus. There was no significant difference of viral detection rate between the two groups (P=0.577).Conclusion: Respiratory viruses can be detected in BALF of children with PBB, However, there is no evidence that PBB is virus-induced.