[Peptic ulcer recurrence after successful eradication of Helicobacter pylori--clinical characteristics and management].
[Peptic ulcer recurrence after successful eradication of Helicobacter pylori--clinical characteristics and management].
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成功根除幽门螺杆菌后消化性溃疡复发——临床特征与治疗
DOI：
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
T. Arakawa
中科院分区：
文献类型：
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作者：
Toshio Watanabe;K. Higuchi;K. Tominaga;Y. Fujiwara;T. Arakawa
成功根除幽门螺杆菌（H。pylori）并不罕见。评价了H.幽门螺杆菌根除对预防胃溃疡复发的作用。256例中20例溃疡复发。根除幽门者溃疡复发时间多在根除后1年内。非甾体类抗炎药和心理压力，而不是性别，吸烟习惯，饮酒习惯，溃疡的过去的历史，似乎与溃疡复发。根除H. pylori常复发。一些复发性溃疡对H2受体拮抗剂或质子泵抑制剂治疗无效。成功根除H. pylori仍不清楚。
Peptic ulcer recurrence after successful eradication of Helicobacter pylori(H. pylori) is not rare. We evaluated the effect of H. pylori eradication on prevention of gastric ulcer recurrence. Ulcer recurrence had occurred in 20 of 256 H. pylori-eradicated patients, and most of ulcer recurrence were found within 1 year after eradication. NSAIDs and psychological stress, but not sex, smoking habit, drinking habit, and past history of ulcer, seem to be associated with ulcer recurrence. Intractable ulcers after the eradication of H. pylori frequently recurred. Some recurrent ulcers were refractory to treatment with H2-receptor antagonists or proton pump inhibitors. The mechanism(s) by which healed ulcers recur after successful eradication of H. pylori remains unclear.