CORRELATION BETWEEN SERUM IGG-2 CONCENTRATIONS AND THE ANTIBODY-RESPONSE TO BACTERIAL POLYSACCHARIDE ANTIGENS
CORRELATION BETWEEN SERUM IGG-2 CONCENTRATIONS AND THE ANTIBODY-RESPONSE TO BACTERIAL POLYSACCHARIDE ANTIGENS
复制标题
DOI：
10.1056/nejm198007243030402
复制
发表时间：
1980-01-01
影响因子：
158.5
通讯作者：
SCHIFFMAN, G
中科院分区：
文献类型：
--
作者：
SIBER, GR;SCHUR, PH;SCHIFFMAN, G
本文测定了53例霍奇金-S病患者和10例健康成人血清免疫球蛋白[Ig]类和Ig G亚类的浓度，并探讨了这些类和亚类与受试者对细菌多糖和病毒蛋白抗原的抗体应答的关系。同时接受放射治疗和化疗的患者的免疫球蛋白2亚类的平均水平显著低于对照组(P<；0.05)。免疫前Ig G-2水平与对11种肺炎球菌抗原的平均抗体应答(r=0.71，P<；0.001)和对流感嗜血杆菌b型抗原的平均抗体应答(r=0.4，P<；0.01)呈正相关。10例健康成人血清Ig G-2水平与肺炎球菌抗体应答呈显著正相关(r=0.70，P<；0.05)。NO Ig类或亚类与流感A/Victoria/75和A/New Jersey/76血凝素的抗体反应显著相关，这两种血凝素都是蛋白质抗原。血清中的免疫球蛋白-2的浓度似乎可以预测产生多糖类抗体的能力，但不能预测病毒蛋白抗原的产生能力。
Serum concentrations of immunoglobulin [Ig] classes and IgG subclasses were measured in 53 patients who completed treatment for Hodgkin''s disease and in 10 healthy adults. The relation of these classes and subclasses to the subjects'' antibody responses to bacterial polysaccharide and viral protein antigens was determined. Mean levels of the IgG-2 subclass were significantly lower in patients treated with both radiation and chemotherapy than in controls (P < 0.05). The level of IgG-2 before immunization correlated directly with the mean antibody response to 11 pneumococcal antigens (r = 0.71, P < 0.001) and to the Haemophilus influenzae Type b antigen (r = 0.40, P < 0.01). The correlation between IgG-2 concentration and pneumococcal antibody response was also significant in the 10 healthy adults (r = 0.70, P < 0.05). The levels of no Ig class or subclass correlated significantly with antibody responses to influenza A/Victoria/75 and A/New Jersey/76 hemagglutinins, both of which are protein antigens. The serum concentration of IgG-2 appears to provide a marker for predicting the ability to produce antibodies to polysaccharide, but not viral protein antigens.