The risk of paradoxical embolism (RoPE) study: initial description of the completed database.
The risk of paradoxical embolism (RoPE) study: initial description of the completed database.
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DOI：
10.1111/j.1747-4949.2012.00843.x
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Kent DM
中科院分区：
文献类型：
--
作者：
Thaler DE;Di Angelantonio E;Di Tullio MR;Donovan JS;Griffith J;Homma S;Jaigobin C;Mas JL;Mattle HP;Michel P;Mono ML;Nedeltchev K;Papetti F;Ruthazer R;Serena J;Weimar C;Elkind MS;Kent DM
检测隐源性卒中（CS）患者卵圆孔未闭（PFO）闭合的获益受到卒中复发率低和PFO在指标事件中因果作用不确定性的阻碍。需要一种方法来预测PFO归因的复发风险。然而，单个数据库中的卒中复发率通常太少，无法支持风险建模。以前对这一人群的研究受到检查复发相关因素的统计学功效低的限制。通过结合现有数据集，开发一个数据库，以支持PFO归因复发风险的建模。我们确定了现有数据库中的研究者，包括接受PFO研究的CS受试者;确定每个数据库中数据的可用性和特征;合作指定了要纳入副动脉栓塞风险（RoPE）数据库的变量;协调了数据库中的变量，并在必要和可行时收集了新的主要数据。RoPE数据库包含来自12个组成数据库的个体临床、影像学和超声心动图数据，包括CS伴（n=1925）和不伴（n=1749）PFO的受试者。在PFO受试者中，共发生381例结局（卒中、TIA、死亡）（中位随访时间= 2.2年）。虽然研究之间的数据收集存在很大差异，但有足够的重叠来定义适用于风险建模的通用变量集。虽然个体研究不足以模拟PFO可归因的复发风险，但研究者之间的合作产生了一个具有足够功效的数据库，以识别PFO相关卒中复发风险最高的患者，这些患者可能从PFO闭合中获得最大的潜在获益。
Detecting a benefit from closure of patent foramen ovale (PFO) in patients with cryptogenic stroke (CS) is hampered by low rates of stroke recurrence and uncertainty about the causal role of PFO in the index event. A method to predict PFO-attributable recurrence risk is needed. However, individual databases generally have too few stroke recurrences to support risk modeling. Prior studies of this population have been limited by low statistical power for examining factors related to recurrence. To develop a database to support modeling of PFO-attributable recurrence risk by combining extant data sets. We identified investigators with extant databases including subjects with CS investigated for PFO; determined the availability and characteristics of data in each database; collaboratively specified the variables to be included in the Risk of Paradoxical Embolism (RoPE) database; harmonized the variables across databases, and collected new primary data when necessary and feasible. The RoPE database has individual clinical, radiologic, and echocardiographic data from 12 component databases including subjects with CS both with (n=1925) and without (n=1749) PFO. In the PFO subjects, a total of 381 outcomes (stroke, TIA, death) occurred (median follow-up = 2.2yrs). While there were substantial variations in data collection between studies, there was sufficient overlap to define a common set of variables suitable for risk modeling. While individual studies are inadequate for modeling PFO-attributable recurrence risk, collaboration between investigators has yielded a database with sufficient power to identify those patients at highest risk for a PFO-related stroke recurrence who may have the greatest potential benefit from PFO closure.
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影响因子：
8.3
作者：
Alsheikh-Ali, Alawi A.;Thaler, David E.;Kent, David M.
通讯作者：
Kent, David M.
影响因子：
2.8
作者：
De Castro, Stefano;Papetti, Federica;Toni, Danilo
通讯作者：
Toni, Danilo
影响因子：
4.8
作者：
Marshall, AC;Lock, JE
通讯作者：
Lock, JE
影响因子：
8.3
作者：
Kent, David M.;Thaler, David E.
通讯作者：
Thaler, David E.
影响因子：
3
作者：
Casaubon, Leanne;McLaughlin, Peter;Jaigobin, Cheryl
通讯作者：
Jaigobin, Cheryl