Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro
Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro
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DOI：
10.1089/ten.2004.10.1287
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发表时间：
2004-07-01
影响因子：
--
通讯作者：
Spector, M
中科院分区：
文献类型：
--
作者：
Gordon, TD;Schloesser, L;Spector, M
本研究的目的是评估11型胶原支架降解率对成年犬软骨细胞体外增殖和生物合成活性的影响。在更快速降解的支架中，细胞数量较少似乎与支架材料随溶解而损失有关。在培养14天后，快速降解支架的每个细胞的蛋白质和蛋白聚糖合成速率与非降解基质的速率相当。这一结果表明，解耦的降解和形成阶段的组织重塑可能会发生在某些情况下。
The objective of this study was to evaluate effects of the degradation rate of type 11 collagen scaffolds on the proliferation and biosynthetic activity of adult canine chondrocytes in vitro. The lower number of cells in more rapidly degrading scaffolds appeared to be related to the loss of scaffold material with dissolution. After 14 days in culture, protein and proteoglycan synthesis rates per cell for rapidly degrading scaffolds were comparable to rates for nondegraded matrices. This result suggests that decoupling of the degradation and formation phases of tissue remodeling may occur under certain circumstances.