The sleep and wake electroencephalogram over the lifespan.
The sleep and wake electroencephalogram over the lifespan.
复制标题
整个生命周期的睡眠和觉醒脑电图。
DOI：
10.1016/j.neurobiolaging.2023.01.006
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发表时间：
2023
影响因子：
4.2
通讯作者：
Westover,MBrandon
中科院分区：
文献类型：
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作者：
Sun,Haoqi;Ye,Elissa;Paixao,Luis;Ganglberger,Wolfgang;Chu,CatherineJ;Zhang,Can;Rosand,Jonathan;Mignot,Emmanuel;Cash,SydneyS;Gozal,David;Thomas,RobertJ;Westover,MBrandon
睡眠和清醒的脑电图（EEG）都会随着人的一生而改变。虽然先前的研究已经描述了脑电图与年龄相关的变化，但数据集跨越了特定的年龄组，或者关注睡眠和清醒的宏观结构而不是微观结构。在这里，我们提供了来自3372名基于社区或临床的神经和精神健康参与者的性别分层数据，年龄从11天到80岁不等。我们估计了睡眠和清醒的关键EEG参数的年龄标准，包括delta、theta、alpha和sigma波段的绝对和相对功率，以及睡眠纺锤波密度、振幅、持续时间和频率。为了说明本文开发的参考措施的潜在用途，我们将其与年龄匹配的阿尔茨海默病、严重睡眠呼吸暂停、抑郁症、骨关节炎和骨质疏松症参与者的睡眠脑电图记录进行了比较。尽管数据集的部分临床性质可能使结果偏向于不太正常的结果，因此在实践中可能低估病理，但基于年龄的脑电图参考值能够客观筛选影响大脑健康的各种疾病个体与健康衰老的偏差。
Both sleep and wake encephalograms (EEG) change over the lifespan. While prior studies have characterized age-related changes in the EEG, the datasets span a particular age group, or focused on sleep and wake macrostructure rather than the microstructure. Here, we present sex-stratified data from 3372 community-based or clinic-based otherwise neurologically and psychiatrically healthy participants ranging from 11 days to 80 years of age. We estimate age norms for key sleep and wake EEG parameters including absolute and relative powers in delta, theta, alpha, and sigma bands, as well as sleep spindle density, amplitude, duration, and frequency. To illustrate the potential use of the reference measures developed herein, we compare them to sleep EEG recordings from age-matched participants with Alzheimer's disease, severe sleep apnea, depression, osteoarthritis, and osteoporosis. Although the partially clinical nature of the datasets may bias the findings towards less normal and hence may underestimate pathology in practice, age-based EEG reference values enable objective screening of deviations from healthy aging among individuals with a variety of disorders that affect brain health.