High Frequency of Depressive Symptoms among Adults with Epilepsy: Results from a Hospital-based Study.
High Frequency of Depressive Symptoms among Adults with Epilepsy: Results from a Hospital-based Study.
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DOI：
10.4103/jnrp.jnrp_21_17
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发表时间：
2017-08
影响因子：
1.4
通讯作者：
Nair PP
中科院分区：
文献类型：
--
作者：
Chandrasekharan SC;Menon V;Wadwekar V;Nair PP
评估癫痫患者（PWE）中抑郁症的共病负担和相关因素有可能为临床评估和管理提供信息，以改善结局。本研究的目的是确定频率的抑郁症状和相关因素之间的PWE参加三级保健医院。这是一项在三级医疗中心门诊进行的横断面观察性研究。2016年5月至2016年8月期间招募了150例癫痫患者。为了评估抑郁症，使用泰米尔语验证版本的患者健康问卷-12。抑郁症的频率及其与各种社会人口统计学和临床因素的关系进行了评估。单因素分析采用Student t检验和卡方检验，多因素分析采用Logistic回归分析。在150例受试者中，89例（59.3%）为男性。全身强直阵挛发作131人（87.3%）。遗传性和不明原因癫痫占44.7%，结构性癫痫占37.3%。大多数患者（88%）正在服用一种或两种抗癫痫药物。31人（20.3%）每年发作少于一次。95例（63.3%）患者存在抑郁症状。多因素回归分析显示，继发性全身性发作和发作频率>1次/月是抑郁症的显著预测因素（[OR]：5.48 [95%CI：1.35-22.28]和OR：2.53 [95%CI：1.11-5.75]）。抑郁症在大多数成年PWE中普遍存在。因此，作为癫痫综合治疗的一部分，对参加门诊的PWE进行常规抑郁症筛查是明智的。
Assessment of comorbid burden of depression and associated factors among adult people living with epilepsy (PWE) has the potential to inform clinical evaluation and management to improve outcomes. The aim of this study is to determine frequency of depressive symptoms and factors associated with it among PWE attending a tertiary care hospital. This was a cross-sectional observational study conducted in the outpatient clinic of a tertiary care center. One hundred and fifty patients with epilepsy were recruited between May 2016 and August 2016. For assessing depression, Tamil validated version of Patient Health Questionnaire-12 was used. Frequency of depression and its association with various sociodemographic and clinical factors were assessed. Student t-test and Chi-square test for univariate analysis and logistic regression for multivariate analysis were used for statistical analysis. Of the 150 subjects, 89 (59.3%) were males. Generalized tonic–clonic seizures were present in 131 people (87.3%). Genetic and unknown epilepsies contributed higher proportion (44.7%) as compared to structural epilepsies (37.3%). Majority (88%) were on one or two antiepileptic drugs. Thirty-one people (20.3%) had less than one seizure per year. Depressive symptoms were present in 95 patients (63.3%). In multivariate regression analysis, secondary generalized seizures and seizure frequency >1/month emerged as significant predictors of depression ([OR]: 5.48 [95% (CI): 1.35–22.28] and OR: 2.53 [95% CI: 1.11–5.75], respectively). Depression is prevalent in a majority of adult PWE. Hence, a routine screening for depression as part of comprehensive epilepsy care is advisable for PWE attending the outpatient clinic.