Modular 3D Printed Compressed Air Driven Continuous-Flow Systems for Chemical Synthesis
Modular 3D Printed Compressed Air Driven Continuous-Flow Systems for Chemical Synthesis
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DOI：
10.1002/ejoc.201900423
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发表时间：
2019-06-23
影响因子：
2.8
通讯作者：
Hilton, Stephen T.
中科院分区：
文献类型：
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作者：
Penny, Matthew R.;Rao, Zenobia X.;Hilton, Stephen T.
在本研究中，我们描述了一种低成本、小占地面积和模块化3D打印连续流系统的开发，该系统可以很容易地附着在现有的搅拌热板上。流量由压缩空气控制，通常存在于所有通风柜中，使其适合合成化学家使用。流动路径的长度和反应停留时间是通过控制空气流量和压力来调节的，并通过添加一个或多个3D打印聚丙烯（PP）圆盘反应器来调节，这些反应器设计用于适应大多数合成实验室中使用的DrySyn Multi-E基座。在一系列SNAr反应中证明了该系统的易用性，易于控制流速和PP反应器的耐溶剂性，以产生取代醚衍生物，突出了该系统的实用性和模块化。
In this present study, we describe the development of a low-cost, small-footprint and modular 3D printed continuous-flow system that readily attaches to existing stirrer hotplates. Flow-rates are controlled by compressed air that is typically present in all fume hoods, making it suitable for use by synthetic chemists. The length of the flow-path and reaction residence time is regulated by control of the air-flow and pressure and by addition of one or more 3D printed polypropylene (PP) circular disk reactors that were designed to fit a DrySyn Multi-E base, which is found in most synthetic laboratories. The ease of use of the system, the facile control of flow-rates and the solvent resistance of the PP reactors was demonstrated in a range of SNAr reactions to produce substituted ether derivatives highlighting the utility and modularity of the system.