Exposure to influenza epidemics during gestation and adult schizophrenia. A 40-year study.
Exposure to influenza epidemics during gestation and adult schizophrenia. A 40-year study.
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DOI：
10.1001/archpsyc.1990.01810210077012
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发表时间：
1990-09
影响因子：
--
通讯作者：
Christopher E. Barr;S. Mednick;Poul Munk-Jorgensen
中科院分区：
文献类型：
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作者：
Christopher E. Barr;S. Mednick;Poul Munk-Jorgensen
我们试图重复早期的发现，在妊娠中期暴露于流感和成人精神分裂症之间的关联。从1911年至1950年，按月确定了向丹麦卫生部报告的活产数、未来精神分裂症患者的出生数和流感病例数。胎儿暴露于流感和成人精神分裂症之间的关系进行了检查。有可能是未知的因素在冬季造成流感和精神分裂症的过度，造成一种人为的联系。为了控制这种巧合，通过几种方法从每月流感和精神分裂症的出生率中去除季节的影响。使用残差分数，发现妊娠第六个月流感发病率高于季节预期，与精神分裂症的出生率高于季节预期相关。这种联系不能归因于某些与冬季有关的第三因素或气候变量。
We attempted to replicate earlier findings of an association between exposure to influenza in the second trimester of gestation and adult schizophrenia. The number of live births, of births of future schizophrenics, and of cases of influenza reported to the Ministry of Health in Denmark was ascertained by month from 1911 to 1950. The relationship between fetal exposure to influenza and adult schizophrenia was examined. It is possible that unknown factors produce excesses of both influenza and schizophrenia in the winter, creating an artifactual association. To control for this coincidence, the effects of season were removed from the monthly influenza and schizophrenic birth-rates by several methods. Using the residual scores, it was found that influenza rates higher than seasonally expected, occurring in the sixth month of gestation, were associated with rates of births of schizophrenics greater than seasonally expected. This association was not attributable to some winter-related, third factor or to climatic variables.