Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells
Lysosome-targeting turn-on red/NIR BODIPY probes for imaging hypoxic cells
复制标题
用于低氧细胞成像的溶酶体靶向开启红色/NIR BODIPY 探针
DOI：
10.1039/c9cc04416g
复制
发表时间：
2019-10-04
影响因子：
4.9
通讯作者：
Lu, Hua
中科院分区：
文献类型：
--
作者：
Kong, Xiangduo;Di, Linting;Lu, Hua
以BODIPY为荧光基团，设计了一系列含吗啉和硝基的荧光溶酶体靶向探针。这些探针发射从绿色到NIR波长的光，并且提供用于对缺氧细胞的溶酶体成像的特异性。吸电子的硝基苯基基团在meso位置被发现，导致高效的非辐射衰减的S-1状态，因此恢复的荧光时，还原的硝基基团发生在缺氧条件下。
A small series of fluorescent lysosome-targeting probes based on the BODIPY fluorophore and containing morpholine and nitro groups were rationally designed. These probes emitted light from green to NIR wavelengths, and provided specificity for imaging the lysosomes of hypoxic cells. The electron-withdrawing nitrophenyl group at the meso position was found to lead to highly efficient nonradiative decay of the S-1 state, and hence a recovery of fluorescence when reduction of the nitro group occurred under hypoxic conditions.