Carboxymethylated--cyclodextrin/chitosan particles: bulk solids and aqueous dispersions
Carboxymethylated--cyclodextrin/chitosan particles: bulk solids and aqueous dispersions
复制标题
羧甲基化--环糊精/壳聚糖颗粒：散装固体和水分散体
DOI：
10.1080/01932691.2019.1611440
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发表时间：
2020
影响因子：
2.2
通讯作者：
J. Fonseca
中科院分区：
文献类型：
--
作者：
R. T. Stopilha;F. Xavier;C. L. de Vasconcelos;J. Fonseca
摘要聚电解质复合物（佩奇）广泛应用于药物、肥料的缓释体系以及纤维和颗粒的表面改性。在这项工作中，PEC分散体由壳聚糖（CS），阳离子生物聚合物，和阴离子环糊精（羧甲基-β-环糊精，CM-β-CD，在这项工作中合成），以获得具有极性区域的颗粒，在离子交联位点周围，和来自环糊精分子内部空腔的疏水区域。采用FTIR、XRD、TGA和MALDI-TOF等手段对材料进行了表征。PEC分散体还通过粘度、ζ电位测量和DLS表征。除了在形成PEC时观察到的通常结晶度损失外，在CS/CM-β-CD复合物的特定情况下，观察到分散固相的剧烈形成，但没有检测到可溶性大分子物质的大分子尺寸最初减小。这种不寻常的行为与本工作中制备的CM-β-CD的高取代度有关。图形摘要
Abstract Polyelectrolyte complexes (PECs) are widely used in systems for the release of drugs, fertilizers as well as in the surface modification of fibers and particles. In this work, PEC dispersions were produced from chitosan (CS), a cationic biopolymer, and an anionic cyclodextrin (carboxymethylated--cyclodextrin, CM-β-CD, synthesized in this work), in order to obtain particles with polar regions, around the ionic crosslinking sites, and hydrophobic regions from cyclodextrin molecules internal cavities. Bulk materials were characterized by FTIR, XRD, TGA, and MALDI-TOF. PEC dispersions were additionally characterized by viscometry, zeta potential measurements, and DLS. Apart from the usual loss of crystallinity observed as PEC is formed, in the specific case of CS/CM-β-CD complex a drastic formation of dispersed solid phase was observed, without the detection of an initial decrease of macromolecular dimensions of soluble macromolecular species. This unusual behavior was associated to the high degree of substitution of the CM-β-CD prepared in this work. Graphical Abstract