Immune-metabolic interaction in Drosophila
Immune-metabolic interaction in Drosophila
复制标题
DOI：
10.4161/fly.28113
复制
发表时间：
2014-04-01
期刊：
影响因子：
1.2
通讯作者：
Dionne, Marc S.
中科院分区：
文献类型：
--
作者：
Dionne, Marc S.
免疫反应和代谢调节在所有动物中都是紧密耦合的，但根本的机制联系还不完全清楚。在苍蝇和人类中，长期或过度的免疫激活会导致代谢中断并导致代谢储备损失。相反，代谢稳态的破坏，如营养不良时期，可能对免疫功能产生重大影响。我们最近发现转录因子MEF2是成年果蝇脂肪体合成代谢和免疫功能之间的关键开关。保守的磷酸化决定了MEF2对TATA结合蛋白的亲和力，影响能量储存和免疫功能之间的选择。本次审查的目的是将这一分子事件在果蝇的代谢免疫相互作用的更广泛的背景下，探索什么是和不知道这2个关键的生理功能之间的联系。
Immune responses and metabolic regulation are tightly coupled in all animals, but the underlying mechanistic connections are nowhere completely clear. In flies and in humans, prolonged or excessive immune activation can drive metabolic disruption and cause loss of metabolic stores. Conversely, disruptions of metabolic homeostasis, such as periods of malnutrition, can have significant impacts on immune function. We have recently identified the transcription factor MEF2 as a critical switch between anabolic and immune function in the adult Drosophila fat body. A conserved phosphorylation determines the affinity of MEF2 for the TATA-binding protein, effecting a choice between energy storage and immune function. The goal of this review is to place this molecular event in the broader context of metabolic-immune interaction in Drosophila, exploring what is and is not known about the ties between these 2 critical physiological functions.