Metastatic sites and survival in lung cancer
Metastatic sites and survival in lung cancer
复制标题
DOI：
10.1016/j.lungcan.2014.07.020
复制
发表时间：
2014-10-01
期刊：
影响因子：
5.3
通讯作者：
Hemminki, K.
中科院分区：
文献类型：
--
作者：
Riihimaeki, M.;Hemminki, A.;Hemminki, K.
目的：由于大多数癌症登记处不记录转移，因此缺乏肺癌和任何癌症的转移部位和部位特异性转移的生存率的基于人群的数据。本研究采用了一种新的人口为基础的方法，以确定从死亡证明和全国住院数据转移到描述转移途径在肺癌patients.Materials和方法：17,431死亡肺癌患者诊断2002-2010年确定从全国范围内的瑞典癌症登记处，这是基于强制性的报告。研究了诊断时年龄、性别和组织学亚型对转移扩散的影响。结果：肺癌转移部位以神经系统、骨、肝、呼吸系统和肾上腺最多见。在小细胞肺癌转移的患者中，肝脏（35%）和神经系统（47%）转移是常见的，腺癌中骨（39%）和呼吸系统（22%）转移是常见的。女性（43%比35%）和年轻患者的神经系统转移更多。非转移性肺癌诊断后的中位生存期为13个月，转移性肺癌为5个月。在这一新的数据中，肝转移的预后最差（3个月），特别是对于大细胞组织学。骨转移瘤的生存率也很差，而呼吸系统和神经系统转移瘤的生存率更好。结论：转移性肺癌的转移部位和生存率受性别、组织学亚型和诊断年龄的影响。与神经系统转移相比，肝和骨转移标志着较差的生存率。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Objectives: Population-based data on metastatic sites and survival in site-specific metastases are lacking for lung cancer and for any cancer because most cancer registries do not record metastases. This study uses a novel population-based approach to identify metastases from both death certificates and national inpatient data to describe metastatic pathways in lung cancer patients.Materials and methods: 17,431 deceased lung cancer patients diagnosed 2002-2010 were identified from the nationwide Swedish Cancer Registry, which is based on compulsory reports. The influence of age at diagnosis, sex, and histological subtype on metastatic spread was investigated. Survival in metastatic lung cancer was assessed by histology and metastatic site.Results: The most frequent metastatic sites were the nervous system, bone, liver, respiratory system, and adrenal gland. Liver (35%) and nervous system (47%) metastases were common in patients with metastases from small cell lung cancer, and bone (39%) and respiratory system (22%) metastases in adenocarcinoma. Women (43% vs. 35%) and younger patients had more metastases to the nervous system. Median survival after diagnosis was 13 months for non-metastatic and five months for metastatic lung cancer. In this novel data, liver metastases conferred the worst prognosis (three months), especially for large cell histology. Bone metastases also featured poor survival, whereas survival in respiratory and nervous system metastases was better.Conclusion: Metastatic sites and survival in metastatic lung cancer is influenced by sex, histological subtype, and age at diagnosis. Liver and bone metastases signal poor survival, compared with nervous system metastases. (C) 2014 Elsevier Ireland Ltd. All rights reserved.