Selective Aspiration or Neurotoxic Lesions of Orbital Frontal Areas 11 and 13 Spared Monkeys' Performance on the Object Discrimination Reversal Task
Selective Aspiration or Neurotoxic Lesions of Orbital Frontal Areas 11 and 13 Spared Monkeys' Performance on the Object Discrimination Reversal Task
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DOI：
10.1523/jneurosci.4655-08.2009
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发表时间：
2009-03-04
影响因子：
5.3
通讯作者：
Bachevalier, Jocelyne
中科院分区：
文献类型：
--
作者：
Kazama, Andy;Bachevalier, Jocelyne
在一些物种中，眼眶额叶皮质(OFC)的损伤长期以来一直与逆转学习缺陷有关。在猴子中，这种损害发生在包括几个OFC亚区的损害之后。然而，OFC亚区的不同连接模式以及人类的神经成像数据表明，特定的OFC区域在处理指导行为所需的信息方面发挥着独特的作用(Kringelbach and Rolls，2004；Barbas，2007；Price，2007)。更具体地说，区域11和13构成了感觉网络，而内侧区域10、14和25则与内脏运动网络紧密相连。为了检验第11区和第13区对逆转学习的贡献，我们在两个版本的ODR任务上使用一个或五个辨别问题来测试选择性损伤这两个OFC区的猴子。我们将它们的表现与假手术对照组和作为手术对照组的神经毒性杏仁核损伤动物的表现进行了比较。无论是对11区和13区的损伤，还是对杏仁核的损伤，都不会影响ODR任务的表现。结果表明，11区和13区对逆转学习没有重要贡献，OFC亚区(10、12、14和25)的邻近损害可能是早期病变研究中发现的ODR缺陷的原因。这种反转学习的节省将与同一动物在操作情感(积极和消极)刺激的相对值时测量行为调节的任务中发现的缺陷有关。
Damage to the orbital frontal cortex (OFC) has long been associated with reversal learning deficits in several species. In monkeys, this impairment follows lesions that include several OFC subfields. However, the different connectional patterns of OFC subfields together with neuroimaging data in humans have suggested that specific OFC areas play distinctive roles in processing information necessary to guide behavior (Kringelbach and Rolls, 2004; Barbas, 2007; Price, 2007). More specifically, areas 11 and 13 contribute to a sensory network, whereas medial areas 10, 14, and 25 are heavily connected to a visceromotor network. To examine the contribution of areas 11 and 13 to reversal learning, we tested monkeys with selective damage to these two OFC areas on two versions of the ODR task using either one or five discrimination problems. We compared their performance with that of sham-operated controls and of animals with neurotoxic amygdala lesions, which served as operated controls. Neither damage to areas 11 and 13 nor damage to the amygdala affected performance on theODRtasks. The results indicate that areas 11 and 13 do not critically contribute to reversal learning and that adjacent damage to OFC subfields (10, 12, 14, and 25) could account for the ODR deficits found in earlier lesion studies. This sparing of reversal learning will be discussed in relation to deficits found in the same animals on tasks that measure behavioral modulation when relative value of affective (positive and negative) stimuli was manipulated.