A genome-wide survey of hybrid incompatibility factors by the introgression of marked segments of Drosophila mauritiana chromosomes into Drosophila simulans.
A genome-wide survey of hybrid incompatibility factors by the introgression of marked segments of Drosophila mauritiana chromosomes into Drosophila simulans.
复制标题
通过将毛里求斯果蝇染色体的标记片段渗入模拟果蝇中，对杂交不相容因素进行全基因组调查。
DOI：
10.1093/genetics/142.3.819
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发表时间：
1996
期刊：
影响因子：
3.3
通讯作者：
Laurie,CC
中科院分区：
文献类型：
--
作者：
True,JR;Weir,BS;Laurie,CC
模拟果蝇 (Drosophila simulans) 和 D.在毛里求斯，雄性不育，雌性可育，符合霍尔丹法则。通过将毛里求斯基因组片段渗入到模拟背景中来研究这种现象的遗传基础。毛里求斯基因组中共有 87 个位置标记有 P 元件插入，并通过与拟人重复回交 15 代进行重复基因渗入。雄性不育的半合X染色体渗入的比例比纯合常染色体片段的比例高约50%。这一结果表明，雄性不育因子在 theX 上以更高的速率进化，但不能排除染色体片段长度的差异。雄性不育的纯合常染色体渗入分数比雌性不育或不能存活的分数大几倍。这一观察有力地表明，雄性不育因素比雌性不育因素或不育因素进化得更快。这些结果与之前对这些物种和其他物种的研究相结合，表明霍尔丹规则至少有两个原因：不亲和因素的隐性和影响雄性和雌性的不育因素的差异积累。
In hybrids betweenDrosophila simulansandD. mauritiana, males are sterile and females are fertile, in compliance with Haldane's rule. The genetic basis of this phenomenon was investigated by introgression of segments of themauritianagenome into asimulansbackground. A total of 87 positions throughout themauritianagenome were marked withP-element insertions and replicate introgressions were made by repeated backcrossing tosimulansfor 15 generations. The fraction of hemizgyousXchromosomal introgressions that are male sterile is ~50% greater than the fraction of homozygous autosomal segments. This result suggests that male sterility factors have evolved at a higher rate on theX, but chromosomal differences in segment length cannot be ruled out. The fraction of homozygous autosomal introgressions that are male sterile is several times greater than the fraction that are either female sterile or inviable. This observation strongly indicates that male sterility factors have evolved more rapidly than either female sterility or inviability factors. These results, combined with previous work on these and other species, suggest that Haldane>'s rule has at least two causes: recessivity of incompatibility factors and differential accumulation of sterility factors affecting males and females.