Influence of subthreshold nonlinearities on signal-to-noise ratio and timing precision for small signals in neurons: minimal model analysis
Influence of subthreshold nonlinearities on signal-to-noise ratio and timing precision for small signals in neurons: minimal model analysis
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阈下非线性对神经元小信号信噪比和定时精度的影响：最小模型分析
DOI：
10.1080/net.14.1.137.150
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
J. Rinzel
中科院分区：
文献类型：
--
作者：
G. Svirskis;J. Rinzel
亚阈值电压和时间依赖性电导可以在信号整合和动作电位产生中发挥不同的作用。在这里，我们使用最小模型来演示非失活低阈值外向电流（IKLT）如何提高小信号积分的精度。我们的综合和火灾模型只有几个生物物理参数，使IKLT的影响的参数研究。当在弱随机输入的存在下递送亚阈值“信号”EPSP时，IKLT增加用于激发的信噪比（SNR）。增加的SNR是由于对随机输入的自发发射的抑制。相应地，SNR随着EPSP幅度的增加而增加。SNR也随着单一突触电流的时间常数增加而增加，从而导致对自发活动的更有效抑制。尖峰触发的注入电流的反向相关性表明，要达到尖峰阈值，具有IKLT的细胞需要较短的注入电流时间过程。与此相一致的窄积分时间窗口，IKLT增强锁相，测量矢量强度，一个弱的噪声和周期性调制的刺激。因此，IKLT介导的阈下负反馈增强了时间加工。另一种抑制机制是低阈值内向电流的电压和时间依赖性失活。与内向电流为非失活的情况相比，积分和激发模型中的此特征也显示SNR增强。在噪声神经元系统中，通过阈下负反馈可以显著改善小信号检测，从而抑制假阳性。
Subthreshold voltage- and time-dependent conductances can subserve different roles in signal integration and action potential generation. Here, we use minimal models to demonstrate how a non-inactivating low-threshold outward current (IKLT) can enhance the precision of small-signal integration. Our integrate-and-fire models have only a few biophysical parameters, enabling a parametric study of IKLT's effects. IKLTincreases the signal-to-noise ratio (SNR) for firing when a subthreshold 'signal' EPSP is delivered in the presence of weak random input. The increased SNR is due to the suppression of spontaneous firings to random input. In accordance, SNR grows as the EPSP amplitude increases. SNR also grows as the unitary synaptic current's time constant increases, leading to more effective suppression of spontaneous activity. Spike-triggered reverse correlation of the injected current indicates that, to reach spike threshold, a cell with IKLT requires a briefer time course of injected current. Consistent with this narrowed integration time window, IKLTenhances phase-locking, measured as vector strength, to a weak noisy and periodically modulated stimulus. Thus subthreshold negative feedback mediated by IKLTenhances temporal processing. An alternative suppression mechanism is voltage-and time-dependent inactivation of a low-threshold inward current. This feature in an integrate-and-fire model also shows SNR enhancement, in comparison with a case when the inward current is non-inactivating. Small-signal detection can be significantly improved in noisy neuronal systems by subthreshold negative feedback, serving to suppress false positives.
影响因子：
2.5
作者：
C. A. D. Negro;S. H. Chandler
通讯作者：
C. A. D. Negro;S. H. Chandler
影响因子：
56.9
作者：
LIBERMAN, MC
通讯作者：
LIBERMAN, MC
结构和功能差异区分了豚鼠 MSO 切片中的主要细胞和非主要细胞。
DOI：
10.1152/jn.1995.73.4.1653
发表时间：
1995
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Smith,PH
通讯作者：
Smith,PH