Effect of deciduogenic stimuli on protein secretion by the mouse uterus.
Effect of deciduogenic stimuli on protein secretion by the mouse uterus.
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DOI：
10.1530/jrf.0.0840273
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发表时间：
1988-09
期刊：
影响因子：
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通讯作者：
G. L. Nieder
中科院分区：
文献类型：
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作者：
G. L. Nieder
将油注入孕酮诱导的雌激素敏感的小鼠子宫中，结果显示分泌模式与怀孕第5天发现的相似，但不完全相同。妊娠和实验性蜕膜细胞反应常见的刺激依赖反应包括早期但短暂的40,000 mR基本蛋白增加和另外两种蛋白减少。在黄体酮维持的“非接受性”子宫中注入油后，也发现了一些特征性的变化，尽管随后没有发生蜕膜化。另一种蜕膜致病物质霍乱毒素的滴注也导致了与怀孕相似的模式，包括增加了25,000 mR酸性蛋白的分泌，这种蛋白只在石油诱导的蜕膜细胞反应中产生最低限度。
Instillation of oil into progesterone-primed, oestrogen-sensitized uteri of mice resulted in secretion patterns which were similar, but not identical, to those found on Day 5 of pregnancy. Stimulus-dependent responses common to pregnancy and the experimental decidual cell reaction included an early but transient increase in a 40,000 Mr basic protein and decreases in two other proteins. Some of the characteristic changes were also found after oil instillation in the progesterone-maintained 'non-receptive' uterus, even though subsequent decidualization did not occur. Instillation of cholera toxin, another deciduogenic substance, also resulted in patterns similar to those of pregnancy, including an increased secretion of a 25,000 Mr acidic protein which was only minimally produced during the oil-induced decidual cell reaction.