Synch before you speak: Auditory hallucinations in schizophrenia
Synch before you speak: Auditory hallucinations in schizophrenia
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DOI：
10.1176/appi.ajp.164.3.458
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发表时间：
2007-03-01
影响因子：
17.7
通讯作者：
Mathalon, Daniel H.
中科院分区：
文献类型：
--
作者：
Ford, Judith M.;Roach, Brian J.;Mathalon, Daniel H.
目的：在自生成动作之前的神经活动的同步可以反映前向模型的操作，前向模型用于抑制由这些动作产生的感觉。如果这是真的，动作前的同步性应该与随后的感觉抑制有关。这种机制的缺陷可能是精神分裂症的特征，并与阳性症状有关，如幻听。如果是这样的话，精神分裂症患者在运动之前的神经同步性应该会降低，特别是有严重幻觉的患者。在24例精神分裂症或情感障碍患者和25例健康对照者中，作者将语前神经同步性与随后的听觉皮层对语音的反应性联系起来，比较了精神分裂症患者和健康对照者的语前神经同步性，并将患者的语前神经同步性与幻听的严重程度相关联。为了评估神经同步性，在重复试验中在单个站点计算谈话前单次试验EEG的相位相干性。为了评估听觉皮层抑制，N1事件相关的脑电位，以语音声音发作在谈话和listening.Results：在健康的比较科目，prespeech神经同步性相关的后续抑制的反应，以口语的声音，反映在减少N1在谈话期间相对于听。有更大的prespeech同步在比较科目比患者，特别是那些严重的幻听.Conclusions：这些数据表明，EEG同步之前的语音反映了一个前向模型系统的行动，这抑制了自我产生的语音的听觉反应，是缺乏患者谁产生幻觉。
Objective: Synchronization of neural activity preceding self-generated actions may reflect the operation of the forward model, which acts to dampen sensations resulting from those actions. If this is true, pre-action synchrony should be related to subsequent sensory suppression. Deficits in this mechanism may be characteristic of schizophrenia and related to positive symptoms, such as auditory hallucinations. If so, schizophrenia patients should have reduced neural synchrony preceding movements, especially patients with severe hallucinations.Method: In 24 patients with schizophrenia or schizoaffective disorder and 25 healthy comparison subjects, the authors related prespeech neural synchrony to subsequent auditory cortical responsiveness to the spoken sound, compared prespeech neural synchrony in schizophrenia patients and healthy comparison subjects, and related prespeech neural synchrony to auditory hallucination severity in patients. To assess neural synchrony, phase coherence of single-trial EEG preceding talking was calculated at a single site across repeated trials. To assess auditory cortical suppression, the N1 event-related brain potentials to speech sound onset during talking and listening were compared.Results: In healthy comparison subjects, prespeech neural synchrony was related to subsequent suppression of responsiveness to the spoken sound, as reflected in reduction of N1 during talking relative to listening. There was greater prespeech synchrony in comparison subjects than in patients, especially those with severe auditory hallucinations.Conclusions: These data suggest that EEG synchrony preceding speech reflects the action of a forward model system, which dampens auditory responsiveness to self-generated speech and is deficient in patients who hallucinate.