Redrawing the map to novel DILI biomarkers in circulation: Where are we, where should we go, and how can we get there?
Redrawing the map to novel DILI biomarkers in circulation: Where are we, where should we go, and how can we get there?
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DOI：
10.3390/livers1040022
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
McGill MR
中科院分区：
文献类型：
--
作者：
Vazquez JH;McGill MR
Circulating biomarkers of drug-induced liver injury (DILI) have been a focus of research in hepatology over the last decade, and several novel DILI biomarkers that hold promise for certain applications have been identified. For example, glutamate dehydrogenase holds promise as a specific biomarker of liver injury in patients with concomitant muscle damage. It may also be a specific indicator of mitochondrial damage. In addition, microRNA-122 is sensitive for early detection of liver injury in acetaminophen overdose patients. However, recent events in the field of DILI biomarker research have provided us with an opportunity to step back, consider how biomarker discovery has been done thus far, and determine how to move forward in a way that will optimize the discovery process. This is important because major challenges remain in the DILI field and related areas that could be overcome in part by new biomarkers. In this short review, we briefly describe recent progress in DILI biomarker discovery and development, identify current needs, and suggest a general approach to move forward.
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DOI：
10.1002/hep.29802
发表时间：
2019-03
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Church RJ;Kullak-Ublick GA;Aubrecht J;Bonkovsky HL;Chalasani N;Fontana RJ;Goepfert JC;Hackman F;King NMP;Kirby S;Kirby P;Marcinak J;Ormarsdottir S;Schomaker SJ;Schuppe-Koistinen I;Wolenski F;Arber N;Merz M;Sauer JM;Andrade RJ;van Bömmel F;Poynard T;Watkins PB
通讯作者：
Watkins PB
影响因子：
2.2
作者：
Bhattacharyya S;Yan K;Pence L;Simpson PM;Gill P;Letzig LG;Beger RD;Sullivan JE;Kearns GL;Reed MD;Marshall JD;Van Den Anker JN;James LP
通讯作者：
James LP
影响因子：
6.7
作者：
Craig, Darren G. N.;Lee, Patricia;Simpson, Kenneth J.
通讯作者：
Simpson, Kenneth J.
影响因子：
15.9
作者：
KARMEN, A;WROBLEWSKI, F;LADUE, JS
通讯作者：
LADUE, JS
对乙酰氨基酚过量且预后不良的患者的血清线粒体生物标志物和损伤相关分子模式较高。
影响因子：
13.5
作者：
McGill, Mitchell R.;Staggs, Vincent S.;Sharpe, Matthew R.;Lee, William M.;Jaeschke, Hartmut
通讯作者：
Jaeschke, Hartmut