Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma.
Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma.
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横纹肌肉瘤患者的中枢神经系统 EBV 淋巴增殖性疾病。
DOI：
10.1111/ped.12812
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Inagaki J.
中科院分区：
文献类型：
--
作者：
Nakashima K;Kodama Y;Nishikawa T;Nishimura M;Ito N;Fukano R;Nomura Y;Ueba T;Inoue T;Oshima K;Okamura J;Inagaki J.
eb病毒相关淋巴细胞增生性疾病（EBV - LPD）发生于免疫缺陷患者，但在接受实体瘤化疗的患者中尚未得到很好的描述。我们描述了一例横纹肌肉瘤患儿在长春新碱、放线菌素D和环磷酰胺联合化疗期间发生孤立性中枢神经系统EBV - LPD。患者接受高剂量甲氨蝶呤（HD - MTX）治疗中枢神经系统EBV - LPD，然后由于肝脏出现LPD，在HD - MTX的基础上再接受利妥昔单抗治疗。静脉注射利妥昔单抗联合HD - MTX可能是治疗中枢神经系统EBV - LPD的有效方法。
Epstein–Barr virus associated lymphoproliferative disorder (EBV‐LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV‐LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high‐dose methotrexate (HD‐MTX) for CNS EBV‐LPD and then treated with rituximab in addition to HD‐MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD‐MTX might be effective therapy for CNS EBV‐LPD.