SEPARABLE ROLES OF HIPPOCAMPAL GRANULE CELLS IN FORGETTING AND PYRAMIDAL CELLS IN REMEMBERING SPATIAL INFORMATION
SEPARABLE ROLES OF HIPPOCAMPAL GRANULE CELLS IN FORGETTING AND PYRAMIDAL CELLS IN REMEMBERING SPATIAL INFORMATION
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DOI：
10.1016/0006-8993(87)90717-7
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发表时间：
1987-04-21
期刊：
影响因子：
2.9
通讯作者：
ROUTTENBERG, A
中科院分区：
文献类型：
--
作者：
COLLIER, TJ;QUIRK, GJ;ROUTTENBERG, A
为了研究单个海马细胞群在空间信息记忆处理中的作用，我们在选定的时间前后采集径向迷宫赢得停留任务的解决方案，对背侧海马的颗粒细胞、CA3和CA1锥体细胞进行低强度电刺激。刺激的任何3个细胞群产生了一个可变的持续时间顺行破坏的记忆性能，而刺激的齿状回颗粒细胞单独产生了陈述性记忆特异性逆行性遗忘。颗粒细胞刺激的遗忘效应与海马的后放电无关，并可通过全身给予阿片拮抗剂纳洛酮来预防。我们的研究结果支持这样一种观点，即这种电刺激不会破坏，而是激活颗粒细胞系统的正常功能，导致陈述性记忆中的信息被擦除。相反，锥体细胞系统的类似激活不会产生逆行性遗忘，这表明这些细胞在促进空间信息记忆中的正常作用。
To investigate the roles individual hippocampal cell groups play in processing of spatial information for memory, we administered low-intensity electrical stimulation to the granule cells, CA3 and CA1 pyramidal cells of the dorsal hippocampus at selected times before and after acquisition of the solution to a radial maze win-stay task. Stimulation of any of the 3 cell populations yielded a variable duration anterograde disruption of memory performance, while stimulation of dentate gyrus granule cells alone produced a declarative memory-specific retrograde amnesia. The amnestic effect of granule cell stimulation was not associated with afterdischarges in the hippocampus and was prevented by systemic administration of the opiate antagonist naloxone. Our results support the view that this electrical stimulus does not disrupt, but rather, activates the normal function of the granule cell system, resulting in erasure of information held in declarative memory. In contrast, similar activation of the pyramidal cell system does not yield retrograde amnesia, suggesting a normal role for these cells in promoting memory for spatial information.