Cholinergic innervation in neuritic plaques.
Cholinergic innervation in neuritic plaques.
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DOI：
10.1126/science.6803359
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发表时间：
1982-04
期刊：
影响因子：
56.9
通讯作者：
R. Struble;L. Cork;P. Whitehouse;D. Price
中科院分区：
文献类型：
--
作者：
R. Struble;L. Cork;P. Whitehouse;D. Price
虽然一些阿尔茨海默氏病的研究表明，大脑皮层神经炎性斑块的频率与痴呆的严重程度和减少突触前胆碱能标记在皮层，胆碱能皮质神经支配和斑块的发病机制之间的关系是未知的。该假设进行了测试，在斑块中的神经突组成，部分，突触前胆碱能轴突，其中许多来自基底前脑的神经元。通过分析4 ~ 31岁猴的斑块特征和分布，用乙酰胆碱酯酶染色以及刚果红和银染色来检验这一假设。未成熟斑块和成熟斑块均富含乙酰胆碱酯酶。随着斑块的成熟，淀粉样蛋白的数量增加，神经突的数量和乙酰胆碱酯酶的活性下降。终末期富含淀粉样蛋白的斑块缺乏乙酰胆碱酯酶。这些观察结果表明，皮质胆碱能神经支配的变化是神经炎斑块的发病机制和演变的一个重要特征。
Although several studies of Alzheimer's disease suggest that the frequency of neuritic plaques in the cerebral cortex is correlated with the severity of dementia and with reduction in presynaptic cholinergic markers in the cortex, the relationship between cholinergic cortical innervation and the pathogenesis of plaques is unknown. The hypothesis was tested that the neurites in the plaque consist, in part, of presynaptic cholinergic axons, many of which arise from neurons in the basal forebrain. This hypothesis was tested by analyzing the character and distribution of plaques in monkeys, aged 4 to 31 years, with staining for acetylcholin-esterase and also with Congo red and silver stains. Immature and mature plaques were rich in acetylcholinesterase. As the plaques matured, the amount of amyloid increased, and the number of neurites and the activity of acetylcholinesterase decreased. End-stage amyloid-rich plaques lacked acetylcholinesterase. These observations indicate that changes in cortical cholinergic innervation are an important feature in the pathogenesis and evolution of the neuritic plaque.